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The pattern of gene expression and possible relation of steroidogenic genes in oligodendroglial tumors

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dc.contributor.authorSeol, Ho Jun-
dc.contributor.authorKim, Jeong Eun-
dc.contributor.authorWang, Kyu-Chang-
dc.contributor.authorKim, Seung-Ki-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorJung, Hee-Won-
dc.contributor.authorSeo, Jeong-Sun-
dc.date.accessioned2012-06-26T00:17:43Z-
dc.date.available2012-06-26T00:17:43Z-
dc.date.issued2009-01-
dc.identifier.citationINTERNATIONAL JOURNAL OF ONCOLOGY; Vol.34 1; 181-190ko_KR
dc.identifier.issn1019-6439-
dc.identifier.urihttp://hdl.handle.net/10371/77408-
dc.description.abstractSteroidogenic acute regulatory protein (StAR) regulates the rate-determining step of steroidogenesis. StAR is expressed at a very low level in the white matter of the normal human brain, but is highly expressed in several brain neoplasms including oligodendroglioma (OD). The aim of this study was to identify the different patterns of gene expression low-grade OD and high-grade OD. We carried out gene expression profiling and analyzed the data. In addition, real-time PCR using SIAR primer and immunofluorescent study for StAR were performed. There was a difference in genetic expression between low- and high-grade ODs. An elevated expression of several genes involved in lipid and steroid synthesis, compared with normal white matter, was observed. The expression of such genes showed a tendency either of decreasing or mildly increasing, in high-grade ODs, compared with low-grade ODs. Real-time PCR showed that expression of StAR was relatively low in high-grade ODs, in comparison with low-grade ODs. The pattern of expression between low- and high-grade ODs can differ. This study suggests that the mechanism of neurosteroids synthesis through StAR can be related to the growth of ODs.ko_KR
dc.description.sponsorshipThis study was supported by a grant of the Seoul National
University Hospital (grant number: 32004031).
ko_KR
dc.language.isoenko_KR
dc.publisherPROFESSOR D A SPANDIDOSko_KR
dc.subjectgene expression profilingko_KR
dc.subjectoligodendroglial tumorko_KR
dc.subjectneurosteroidko_KR
dc.subjectsteroidogenicko_KR
dc.subjectacute regulatory proteinko_KR
dc.titleThe pattern of gene expression and possible relation of steroidogenic genes in oligodendroglial tumorsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor설호준-
dc.contributor.AlternativeAuthor김정은-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor김승기-
dc.contributor.AlternativeAuthor서정선-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor정희원-
dc.identifier.doi10.3892/ijo_00000140-
dc.citation.journaltitleINTERNATIONAL JOURNAL OF ONCOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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