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Serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pentraxin 3 (PTX3) as markers of infection in febrile patients with systemic lupus erythematosus

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Authors
Kim, J.; Koh, J. K.; Lee, E. Y.; Park, J. A.; Lee, E. B.; Cotena, A.; Song, Y. W.; Garlanda, C.; Kim, H. A.
Issue Date
2009-10
Publisher
CLINICAL & EXPER RHEUMATOLOGY
Citation
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; Vol.27 5; 773-778
Keywords
Human TREM1 proteinPTX3 proteinfeversystemic lupus erythematosus
Abstract
Objective To investigate the role of sTREM-1 and PTX3 as markers of injection in febrile patients with SLE Methods In febrile (body temperature >= 38 degrees C) patients with SLE, blood samples of day 0, 1, 2, and 14 after presentation were drawn and relevant clinical data were, collected. The patients were allocated to an infection group (n=19) or disease flare group (n=14). Serum levels of sTREM-1 and PTX3 were measured by ELISA using the serum samples of SLE patients and age-and sex-matched healthy controls (n=31). Results A total of 33 febrile episodes occurred in 32 SLE patients (19 infections, 14 flares) were studied. sTREM-1 levels oil day 0 were, significantly higher in the infection group than in the flare group (109.9 pg/ml (median) vs. 48.0 pg/ml, p=0.002), but PTX3 levels were similar in these two groups. The difference of sTREM-1 levels between infection group and flare group was persistent on day 1 and 2 (day 1, p=0.007; day 2, p=0.034). The highest diagnostic value (sensitivity=1.0, specificity=0.664) of sTREM-1 was obtained at the threshold value of 53.2 pg/mL. Conclusion Sertan sTREM-1 levels were significantly higher in the infection group than in the flare group of febrile SLE patients. Our findings suggest that serum sTREM-1 levels could be used to determine whether SLE patients have contracted an infection.
ISSN
0392-856X
Language
English
URI
https://hdl.handle.net/10371/77419
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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