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Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis
DC Field | Value | Language |
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dc.contributor.author | Jin, Cheng-Hao | - |
dc.contributor.author | Chae, Su Young | - |
dc.contributor.author | Kim, Tae Hyung | - |
dc.contributor.author | Yang, Han-Kwang | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.contributor.author | Lee, Kang Choon | - |
dc.contributor.author | Jo, Dong-Gyu | - |
dc.contributor.author | Lee, Eun Young | - |
dc.date.accessioned | 2012-06-26T04:56:24Z | - |
dc.date.available | 2012-06-26T04:56:24Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.citation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS; Vol.332 3; 858-865 | ko_KR |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77423 | - |
dc.description.abstract | This study focused on the potential therapeutic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on collagen-induced arthritis (CIA) and on the elucidation of the mechanisms involved. DBA/1J mice with established CIA were treated with various amount of recombinant soluble human TRAIL. The effects of TRAIL on the development and severity of CIA in this DBA/1J mouse model were assessed clinically and histologically, and a detailed investigation was conducted on proinflammatory cytokine and anticollagen-specific antibody levels. Cellular immunity was evaluated by investigating the proliferative responses and cytokine release profiles of splenocytes after TRAIL treatment. TRAIL treatment significantly reduced the severity and incidence of CIA, joint swelling, erythema, and edema. Histologic evaluations revealed that inflammatory cell infiltration, cartilage destruction, and bone erosion were significantly reduced in joints of TRAIL-treated mice with dose-dependent manner. TRAIL treatment also strongly decreased and/or normalized the productions of proinflammatory cytokines and of anti-collagen-specific antibodies in the sera of CIA mice. Furthermore, in vitro studies with primary splenocytes showed the cytotoxic effect of TRAIL on activated lymphocytes, with reduction of inflammatory cytokine release. These findings show that TRAIL administration is an effective anti-inflammatory treatment that prevents the development and progression of CIA in DBA/1J mice, and they suggest that TRAIL might be considered a potential treatment for human RA. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS | ko_KR |
dc.title | Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 채수영 | - |
dc.contributor.AlternativeAuthor | 김태형 | - |
dc.contributor.AlternativeAuthor | 양한광 | - |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.contributor.AlternativeAuthor | 조동규 | - |
dc.contributor.AlternativeAuthor | 이강춘 | - |
dc.identifier.doi | 10.1124/jpet.109.159517 | - |
dc.citation.journaltitle | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.description.citedreference | Youn YS, 2007, BIOTECHNOL LETT, V29, P713, DOI 10.1007/s10529-006-9300-7 | - |
dc.description.citedreference | Martinez-Lorenzo MJ, 2007, CLIN IMMUNOL, V122, P28, DOI 10.1016/j.clim.2006.07.007 | - |
dc.description.citedreference | Yao QP, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar1867 | - |
dc.description.citedreference | Borchers AT, 2004, SEMIN ARTHRITIS RHEU, V34, P465, DOI 10.1016/j.semarthrit.2003.12.003 | - |
dc.description.citedreference | Evans CH, 2004, GENE THER, V11, P735, DOI 10.1038/sj.gt.3302256 | - |
dc.description.citedreference | Li EK, 2004, CLIN THER, V26, P447 | - |
dc.description.citedreference | Liu ZG, 2003, J CLIN INVEST, V112, P1332, DOI 10.1172/JCI2003219209 | - |
dc.description.citedreference | Tsokos GC, 2003, J CLIN INVEST, V112, P1315, DOI 10.1172/JCI200320297 | - |
dc.description.citedreference | Brand DD, 2003, SPRINGER SEMIN IMMUN, V25, P3, DOI 10.1007/s00281-003-0127-1 | - |
dc.description.citedreference | Lamhamedi-Cherradi SE, 2003, NAT IMMUNOL, V4, P255, DOI 10.1038/ni894 | - |
dc.description.citedreference | Mackay F, 2002, CURR OPIN IMMUNOL, V14, P783 | - |
dc.description.citedreference | Genovese MC, 2002, ARTHRITIS RHEUM, V46, P1443, DOI 10.1002/art.10308 | - |
dc.description.citedreference | Lunemann JD, 2002, J IMMUNOL, V168, P4881 | - |
dc.description.citedreference | Luross JA, 2001, IMMUNOLOGY, V103, P407 | - |
dc.description.citedreference | Lipsky PE, 2000, NEW ENGL J MED, V343, P1594 | - |
dc.description.citedreference | Song KM, 2000, J EXP MED, V191, P1095 | - |
dc.description.citedreference | Ashkenazi A, 1999, CURR OPIN CELL BIOL, V11, P255 | - |
dc.description.citedreference | Griffith TS, 1998, CURR OPIN IMMUNOL, V10, P559 | - |
dc.description.citedreference | Ashkenazi A, 1998, SCIENCE, V281, P1305 | - |
dc.description.citedreference | Emery JG, 1998, J BIOL CHEM, V273, P14363 | - |
dc.description.citedreference | Marsters SA, 1997, CURR BIOL, V7, P1003 | - |
dc.description.citedreference | Chaudhary PM, 1997, IMMUNITY, V7, P821 | - |
dc.description.citedreference | Walczak H, 1997, EMBO J, V16, P5386 | - |
dc.description.citedreference | Cohen GM, 1997, BIOCHEM J, V326, P1 | - |
dc.description.citedreference | Pan GH, 1997, SCIENCE, V277, P815 | - |
dc.description.citedreference | Gura T, 1997, SCIENCE, V277, P768 | - |
dc.description.citedreference | Pan GH, 1997, SCIENCE, V276, P111 | - |
dc.description.citedreference | Campion GV, 1996, ARTHRITIS RHEUM, V39, P1092 | - |
dc.description.citedreference | Feldmann M, 1996, CELL, V85, P307 | - |
dc.description.citedreference | Smolen JS, 1996, SCAND J RHEUMATOL, V25, P1 | - |
dc.description.citedreference | Wiley SR, 1995, IMMUNITY, V3, P673 | - |
dc.description.citedreference | SCHNABEL A, 1994, SEMIN ARTHRITIS RHEU, V23, P310 | - |
dc.description.citedreference | PANAYI GS, 1992, ARTHRITIS RHEUM, V35, P729 | - |
dc.description.citedreference | FIRESTEIN GS, 1990, ARTHRITIS RHEUM, V33, P768 | - |
dc.description.citedreference | HARRIS ED, 1990, NEW ENGL J MED, V322, P1277 | - |
dc.description.tc | 1 | - |
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