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Control of Adipogenesis by the SUMO-Specific Protease SENP2
DC Field | Value | Language |
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dc.contributor.author | Chung, Sung Soo | - |
dc.contributor.author | Ahn, Byung Yong | - |
dc.contributor.author | Kim, Min | - |
dc.contributor.author | Choi, Hye Hun | - |
dc.contributor.author | Kang, Shinae | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Chung, Chin Ha | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Park, Sang Gyu | - |
dc.contributor.author | Park, Ho Seon | - |
dc.date.accessioned | 2012-06-26T05:25:22Z | - |
dc.date.available | 2012-06-26T05:25:22Z | - |
dc.date.issued | 2010-05-01 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOLOGY; Vol.30 9; 2135-2146 | ko_KR |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77430 | - |
dc.description.abstract | Here, we demonstrate that SENP2, a desumoylating enzyme, plays a critical role in the control of adipogenesis. SENP2 expression was markedly increased upon the induction of adipocyte differentiation, and this increase was dependent on protein kinase A activation. Remarkably, knockdown of SENP2 led to a dramatic attenuation of adipogenesis with a marked decrease in PPAR gamma and C/EBP alpha mRNA levels. Knockdown of SENP2 also caused a marked reduction in the level of C/EBP beta protein but not in that of C/EBP beta mRNA. Interestingly, sumoylation of C/EBP beta dramatically increased its ubiquitination and destabilization, and this increase could be reversed by SENP2. In addition, overexpression of C/EBP beta could overcome the inhibitory effect of SENP2 knockdown on adipogenesis. Furthermore, SENP2 was absolutely required for adipogenesis of preadipocytes implanted into mice. These results establish a critical role for SENP2 in the regulation of adipogenesis by desumoylation and stabilization of C/EBP beta and in turn by promoting the expression of its downstream effectors, such as PPAR gamma and C/EBP alpha. | ko_KR |
dc.description.sponsorship | This work was supported by the 21C Frontier Functional Proteomics
Project (M108KM010008-081301-00810), the Korea Science and Engineering Foundation (M10642140004-06N4214-0040), the Ministry of Education, Science and Technology, and grant R31-2008-000-10103-0 from the WCU project of the MEST and the KOSEF. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC MICROBIOLOGY | ko_KR |
dc.title | Control of Adipogenesis by the SUMO-Specific Protease SENP2 | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정성수 | - |
dc.contributor.AlternativeAuthor | 안병용 | - |
dc.contributor.AlternativeAuthor | 김민 | - |
dc.contributor.AlternativeAuthor | 최혜훈 | - |
dc.contributor.AlternativeAuthor | 박호선 | - |
dc.contributor.AlternativeAuthor | 강시내 | - |
dc.contributor.AlternativeAuthor | 박상규 | - |
dc.contributor.AlternativeAuthor | 김영범 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 정진하 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1128/MCB.00852-09 | - |
dc.citation.journaltitle | MOLECULAR AND CELLULAR BIOLOGY | - |
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dc.description.tc | 6 | - |
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