Publications
Detailed Information
Bacteroides fragilis Enterotoxin Induces Human beta-Defensin-2 Expression in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase/I kappa B Kinase/NF-kappa B-Dependent Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Young Mee | - |
dc.contributor.author | Lee, Jin Young | - |
dc.contributor.author | Yoo, Doyoung | - |
dc.contributor.author | Sim, Young-Suk | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Kim, Sunil | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Kang, Ju Seop | - |
dc.contributor.author | Kim, Young-Jeon | - |
dc.date.accessioned | 2012-06-26T05:28:58Z | - |
dc.date.available | 2012-06-26T05:28:58Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | INFECTION AND IMMUNITY; Vol.78 5; 2024-2033 | ko_KR |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77432 | - |
dc.description.abstract | Enterotoxigenic Bacteroides fragilis (ETBF) produces an approximately 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although spontaneous disappearance of ETBF infection is common, little information is available on regulated expression of antibacterial factors in response to BFT stimulation. This study investigates the role of BFT in human beta-defensin 2 (hBD-2) induction from intestinal epithelial cells. Stimulation of HT-29 and Caco-2 intestinal epithelial cell lines with BFT resulted in the induction of hBD-2. Activation of a reporter gene for hBD-2 was dependent on the presence of NF-kappa B binding sites. In contrast, suppression of AP-1 did not affect hBD-2 expression in BFT-stimulated cells. Inhibition of p38 mitogen-activated protein kinase (MAPK) using SB203580 and small interfering RNA (siRNA) transfection resulted in a significant reduction in BFT-induced I kappa B kinase (IKK)/NF-kappa B activation and hBD-2 expression. Our results suggest that a pathway including p38 MAPK, IKK, and NF-kappa B activation is required for hBD-2 induction in intestinal epithelial cells exposed to BFT, and may be involved in the host defense following infection with ETBF. | ko_KR |
dc.description.sponsorship | This work was supported by a National Research Foundation of
Korea (NRF) grant funded by the government of Korea (MEST) (MRC program no. 2009-0091463) and by the Basic Science Research Program through the NRF funded by the Ministry of Education, Science and Technology (R11-2008-044-01004-0). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC MICROBIOLOGY | ko_KR |
dc.title | Bacteroides fragilis Enterotoxin Induces Human beta-Defensin-2 Expression in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase/I kappa B Kinase/NF-kappa B-Dependent Pathway | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤영미 | - |
dc.contributor.AlternativeAuthor | 이진영 | - |
dc.contributor.AlternativeAuthor | 유도영 | - |
dc.contributor.AlternativeAuthor | 심영숙 | - |
dc.contributor.AlternativeAuthor | 김영전 | - |
dc.contributor.AlternativeAuthor | 오유경 | - |
dc.contributor.AlternativeAuthor | 강주섭 | - |
dc.contributor.AlternativeAuthor | 김선일 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.identifier.doi | 10.1128/IAI.00118-10 | - |
dc.citation.journaltitle | INFECTION AND IMMUNITY | - |
dc.description.citedreference | KIM JM, 2010, LAB INVEST | - |
dc.description.citedreference | Wu SG, 2009, NAT MED, V15, P1016, DOI 10.1038/nm.2015 | - |
dc.description.citedreference | Sears CL, 2009, CLIN MICROBIOL REV, V22, P349, DOI 10.1128/CMR.00053-08 | - |
dc.description.citedreference | Rhee KJ, 2009, INFECT IMMUN, V77, P1708, DOI 10.1128/IAI.00814-08 | - |
dc.description.citedreference | Kim JM, 2009, CLIN EXP IMMUNOL, V155, P541, DOI 10.1111/j.1365-2249.2008.03849.x | - |
dc.description.citedreference | Nuding S, 2009, MICROBES INFECT, V11, P384, DOI 10.1016/j.micinf.2009.01.001 | - |
dc.description.citedreference | Lee JY, 2009, J MOL MED-JMM, V87, P169, DOI 10.1007/s00109-008-0415-2 | - |
dc.description.citedreference | Sears CL, 2008, CLIN INFECT DIS, V47, P797, DOI 10.1086/591130 | - |
dc.description.citedreference | Kim JM, 2008, EUR J IMMUNOL, V38, P2190, DOI 10.1002/eji.200838191 | - |
dc.description.citedreference | Giesemann T, 2008, GASTROENTEROLOGY, V134, P2049, DOI 10.1053/j.gastro.2008.03.008 | - |
dc.description.citedreference | Kim JM, 2008, LAB INVEST, V88, P541, DOI 10.1038/labinvest.2008.16 | - |
dc.description.citedreference | Hale JD, 2007, EXPERT REV ANTI-INFE, V5, P951, DOI 10.1586/14787210.5.6.951 | - |
dc.description.citedreference | Lee JY, 2007, J MOL MED-JMM, V85, P1393, DOI 10.1007/s00109-007-0237-7 | - |
dc.description.citedreference | Kim JM, 2007, INFECT IMMUN, V75, P3373, DOI 10.1128/IAI.01940-06 | - |
dc.description.citedreference | Wehkamp J, 2007, CURR OPIN GASTROEN, V23, P32 | - |
dc.description.citedreference | Kim JM, 2006, EUR J IMMUNOL, V36, P2446, DOI 10.1002/eji.200535808 | - |
dc.description.citedreference | Cash HL, 2006, SCIENCE, V313, P1126, DOI 10.1126/science.1127119 | - |
dc.description.citedreference | Toprak NU, 2006, CLIN MICROBIOL INFEC, V12, P782, DOI 10.1111/j.1469-0691.2006.01494.x | - |
dc.description.citedreference | Wehkamp K, 2006, J INVEST DERMATOL, V126, P121, DOI 10.1038/sj.jid.5700020 | - |
dc.description.citedreference | De Smet K, 2005, BIOTECHNOL LETT, V27, P1337, DOI 10.1007/s10529-005-0936-5 | - |
dc.description.citedreference | Kim JM, 2005, EUR J IMMUNOL, V35, P2648, DOI 10.1002/eji.200526321 | - |
dc.description.citedreference | Schneider JJ, 2005, J MOL MED-JMM, V83, P587, DOI 10.1007/s00109-005-0657-1 | - |
dc.description.citedreference | Sahl HG, 2005, J LEUKOCYTE BIOL, V77, P466, DOI 10.1189/jlb.0804452 | - |
dc.description.citedreference | Wehkamp J, 2004, INFECT IMMUN, V72, P5750, DOI 10.1128/IAI.72.10.5750-5758.2004 | - |
dc.description.citedreference | Wu SG, 2004, INFECT IMMUN, V72, P5832, DOI 10.1128/IAI.72.10.5832-5839.2004 | - |
dc.description.citedreference | Basset C, 2004, DIGEST DIS SCI, V49, P1425 | - |
dc.description.citedreference | Chio CC, 2004, CELL SIGNAL, V16, P565, DOI 10.1016/j.cellsig.2003.10.003 | - |
dc.description.citedreference | Howell SJ, 2003, PEPTIDES, V24, P1763, DOI 10.1016/j.peptides.2003.07.028 | - |
dc.description.citedreference | Park KJ, 2003, J BIOL CHEM, V278, P35272, DOI 10.1074/jbc.M305095200 | - |
dc.description.citedreference | Tollin M, 2003, PEPTIDES, V24, P523, DOI 10.1016/S0196-9781(03)00114-1 | - |
dc.description.citedreference | KIM JM, 2003, AM J PHYSIOL-GASTR L, V285, P1171 | - |
dc.description.citedreference | Kim JM, 2002, CLIN EXP IMMUNOL, V130, P59 | - |
dc.description.citedreference | Krisanaprakornkit S, 2002, J IMMUNOL, V168, P316 | - |
dc.description.citedreference | Kim JM, 2001, CLIN EXP IMMUNOL, V123, P421 | - |
dc.description.citedreference | Wada A, 2001, CELL MICROBIOL, V3, P115 | - |
dc.description.citedreference | Prindiville TP, 2000, EMERG INFECT DIS, V6, P171 | - |
dc.description.citedreference | Kim JM, 2000, SCAND J INFECT DIS, V32, P643 | - |
dc.description.citedreference | O`Neil DA, 1999, J IMMUNOL, V163, P6718 | - |
dc.description.citedreference | Wada A, 1999, BIOCHEM BIOPH RES CO, V263, P770 | - |
dc.description.citedreference | Zhang GM, 1999, CLIN INFECT DIS, V29, P590 | - |
dc.description.citedreference | Elewaut D, 1999, J IMMUNOL, V163, P1457 | - |
dc.description.citedreference | Bals R, 1999, INFECT IMMUN, V67, P3542 | - |
dc.description.citedreference | Kim JM, 1997, SCAND J IMMUNOL, V45, P613 | - |
dc.description.citedreference | Niyogi SK, 1997, INDIAN J MED RES, V105, P167 | - |
dc.description.citedreference | Eckmann L, 1996, J IMMUNOL, V156, P2894 | - |
dc.description.citedreference | BROWN PH, 1993, ONCOGENE, V8, P877 | - |
dc.description.citedreference | MYERS LL, 1987, AM J VET RES, V48, P774 | - |
dc.description.tc | 6 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.