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Receptor activator of nuclear factor kappa B ligand-mediated osteoclastogenesis is elevated in ankylosing spondylitis

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Authors
Im, C. H.; Kang, E. H.; Ki, J. Y.; Shin, D. W.; Chang, E. J.; Lee, Y. J.; Kim, H. H.; Song, Y. W.; Lee, E. B.; Lee, E. Y.; Choi, H. J.
Issue Date
2009-08
Publisher
CLINICAL & EXPER RHEUMATOLOGY
Citation
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; Vol.27 4; 620-625
Keywords
Ankylosing spondylitisRANKLosteoclastogenesisTNF-alpha
Abstract
Objective Ankylosing spondylitis (AS) is an inflammatory arthritis involving the axial skeleton. Decreased bone mineral density has also been reported in AS patients. This study sought to determine whether osteoclastogenesis and osteoclast activity are increased in AS. Methods Twenty patients with AS were evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and other clinical parameters. Mononuclear cells were separated out from peripheral blood samples taken from AS patients and normal healthy controls and cultured with monocyte colony stimulating factor and receptor activator of the nuclear factor kappa B ligand (RANKL). Multi-nucleated, tartrate-resistant acid phosphatase stain-positive osteoclasts were counted after 9 days, and the areas of calcium absorption oil calcium-coated plates were determined. Results Osteoclastogenesis was significantly greater in AS patients than in normal controls (number of osteoclasts/1 x 10(6) mononuclear cells, median, 518.0 vs. 362.5, p=0.036). No differences were observed between AS patients and controls in terms of calcium absorption areas or the serum concentrations of tumor necrosis factor-alpha and RANKL. Osteoclastogenesis was greater in AS patients with sacroiliac joint ankylosis than in those without. Osteoclastogenesis and the calcium absorption area were not found to be correlated with BASDAI nor with other clinical parameters including age, erythrocyte sedimentation rate, and C-reactive protein levels. Conclusion Osteoclastogenesis is elevated in AS patients, especially in those with sacroiliac joint ankylosis. Increased osteoclastogenesis may be related to osteopenia in AS patients.
ISSN
0392-856X
Language
English
URI
http://hdl.handle.net/10371/77433
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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