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Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics

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dc.contributor.authorKim, Jin-Moo-
dc.contributor.authorPark, Byung-Lae-
dc.contributor.authorPark, Se-Min-
dc.contributor.authorLee, Shin-Hwa-
dc.contributor.authorJung, Seok-
dc.contributor.authorUh, Soo-Taek-
dc.contributor.authorChoi, Jae-Sung-
dc.contributor.authorKim, Mi-Kyeong-
dc.contributor.authorCho, Sang Heon-
dc.contributor.authorPark, Choon-Sik-
dc.contributor.authorShin, Hyoung Doo-
dc.contributor.authorChang, Hun Soo-
dc.contributor.authorPark, Hae-Sim-
dc.contributor.authorChoi, Byoung Whui-
dc.contributor.authorChoi, Inseon S.-
dc.contributor.authorKim, Yong-Hoon-
dc.contributor.authorPark, Jong Sook-
dc.contributor.authorLee, Eun Hee-
dc.contributor.authorKim, Myung-Ok-
dc.date.accessioned2012-06-26T05:41:19Z-
dc.date.available2012-06-26T05:41:19Z-
dc.date.issued2010-07-
dc.identifier.citationPHARMACOGENOMICS; Vol.11 7; 951-958ko_KR
dc.identifier.issn1462-2416-
dc.identifier.urihttps://hdl.handle.net/10371/77436-
dc.description.abstractAims: Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma. Materials & methods: Asthmatics (n = 438) were categorized into aspirin-intolerant asthma (15% or greater decrease in the forced expiratory volume in 1 s or cutaneous reactions, n = 170) or aspirin-tolerant asthma (n = 268) groups. In total, 14 polymorphisms of the NAT2 gene were genotyped by a single-base extension method. Results: The distributions of all loci of the 14 SNPs were in Hardy-Weinberg equilibrium (p > 0.05). Among the 14 SNPs, six common SNPs (minor allele frequency >5%) in a Korean population were used for haplotype construction and further statistical analysis. The logistic regression analysis demonstrated that NAT2 -9246G>C and haplotype 2 (TCACGG) were significantly associated with the risk of aspirin-intolerant asthma. The rare allele frequencies of the SNP and Ht2 were significantly higher in the aspirin-intolerant asthma group than in the aspirin-tolerant asthma group (pwrr = 0.03 and IV)" = 0.02 in codominant model). Conclusion: In a large genetic epidemiology study of aspirin-intolerant asthma in a Korean population, genetic polymorphisms of NAT2 were found to be related to a risk of aspirin hypersensitivity among asthmatics.ko_KR
dc.language.isoenko_KR
dc.publisherFUTURE MEDICINE LTDko_KR
dc.subjectarylamine N-acetyltransferaseko_KR
dc.subjectaspirin-induced asthmako_KR
dc.subjectcysteinyl leukotrieneko_KR
dc.subjectSNPko_KR
dc.titleAssociation analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmaticsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김진무-
dc.contributor.AlternativeAuthor박병래-
dc.contributor.AlternativeAuthor박세민-
dc.contributor.AlternativeAuthor이신화-
dc.contributor.AlternativeAuthor김명옥-
dc.contributor.AlternativeAuthor정석-
dc.contributor.AlternativeAuthor이은희-
dc.contributor.AlternativeAuthor어수택-
dc.contributor.AlternativeAuthor박종숙-
dc.contributor.AlternativeAuthor최재성-
dc.contributor.AlternativeAuthor김용훈-
dc.contributor.AlternativeAuthor김미경-
dc.contributor.AlternativeAuthor최인선-
dc.contributor.AlternativeAuthor조상헌-
dc.contributor.AlternativeAuthor최병휘-
dc.contributor.AlternativeAuthor박해심-
dc.contributor.AlternativeAuthor장훈수-
dc.contributor.AlternativeAuthor신형두-
dc.contributor.AlternativeAuthor박준식-
dc.identifier.doi10.2217/PGS.10.65-
dc.citation.journaltitlePHARMACOGENOMICS-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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