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Imbalance of Th17 to Th1 cells in Behcet`s disease

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Authors
Kim, J.; Park, J. A.; Lee, E. Y.; Lee, Y. J.; Lee, E. B.; Song, Y. W.
Issue Date
2010-08
Publisher
CLINICAL & EXPER RHEUMATOLOGY
Citation
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; Vol.28 4; S16-S19
Keywords
Behcet`s syndromeflow cytometryinterferoninterleukin-17uveitis
Abstract
Objectives. Behcet`s disease (BD) is a helper T cell-mediated autoimmune disease characterised by recurrent oro-genital ulcers, uveitis and skin lesions. The helper T cells are divided into Th1, Th2 and Th17 cells according to the pattern of cytokine secretion. Th1 and Th17 cells can contribute to the development of the disease with their respective proinflammatory cytokines, IFN-gamma and IL-17. In this study, we investigated the relative role of Th17, Th1 and Th2 cells in BD. Methods. Peripheral blood mononuclear cells were isolated from 30 patients with BD, for whom the detailed clinical manifestations and medication history were investigated and recorded. Surface markers and intracellular levels of IL-17, IFN-gamma and IL-4 in isolated CD4(+) T cells were measured using flow-cytometry from these patients and from two control groups, 34 rheumatoid arthritis patients and 24 healthy blood donors to analyse the relationship of Th1, Th17 and Th2 cells in BD. Results. The ratio of Th17/Th1 cells was significantly increased in BD compared to healthy controls (0.16 +/- 0.09 vs. 0.10 +/- 0.04, p=0.012), while there was no difference in the ratios of Th1/Th2 or Th17/Th2 cells. Th17/Th1 ratio was elevated in BD patients with uveitis or folliculitis compared to those without it (0.21 +/- 0.10 vs. 0.13 +/- 0.06, p=0.045 for uveitis; 0.18 +/- 0.10 vs. 0.12 +/- 0.05, p=0.036 for folliculitis). Conclusion. Our results confirm that TH17 cells are instrumental in Behcet`s uveitis and folliculitis. Furthermore, our findings suggest that the role of Th17 cells should be interpreted in the context of their ratio to Th1 cells.
ISSN
0392-856X
Language
English
URI
https://hdl.handle.net/10371/77438
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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