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Effects of compression/stretching of the spermatic cord and blunt dissection on testicular growth and fertility

Cited 4 time in Web of Science Cited 5 time in Scopus
Authors
Choi, Seung-Eun; Kook, Myeong-Cherl; Kim, Chong Jai; Lee, Seong-Cheol; Jung, Sung-Eun; Kim, Woo-Ki; Park, Kwi-Won
Issue Date
2009-11
Publisher
W B SAUNDERS CO-ELSEVIER INC
Citation
JOURNAL OF PEDIATRIC SURGERY; Vol.44 11; 2163-2167
Keywords
Spermatic cordFertilityCompression/stretchingBlunt dissectionTesticular growth
Abstract
Purpose: This study was performed to investigate whether compression/stretching of the spermatic cord or blunt dissection influences testicular development and fertility. In addition, the authors evaluated whether the extents of testicular damage differ between these 2 surgical manipulations. Methods: Forty-four prepubertal male Sprague-Dawley (SD) rats (Harlan Sprague-Dawley Inc, Indianapolis, Ind) were divided into 3 groups: (1) the control group (CG) animals underwent a sham operation in the right groin, (2) the experimental group 1 (EG1) underwent compression/stretching of the right spermatic cord, and (3) the experimental group 2 (EG2) underwent dissection around the right spermatic cord structures. Testicular volumes, weights, mean seminiferous tubular diameters (MSTDs), mean testicular biopsy scores, and numbers of offspring and of pregnant females were evaluated. Results: Right (operative) and left (nonoperative) testicular volumes were smaller in the EG2 group than in the CG or EG1 groups. Left MSTDs in the EG1 and EG2 groups increased more than in the CG group. Numbers of Sertoli cells in left testes differed in the 3 groups, in the order EG1 < CG < EG2. Mean testicular biopsy scores, offspring numbers, and pregnant female numbers were no different in the 3 groups. Conclusions: Both surgical manipulations influenced testicular growth, but they did not compromise spermatogenesis or fertility in SD rats. (C) 2009 Elsevier Inc. All rights reserved.
ISSN
0022-3468
Language
English
URI
https://hdl.handle.net/10371/77447
DOI
https://doi.org/10.1016/j.jpedsurg.2009.03.025
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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