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Identification of autoantibody against beta-amyloid peptide in the serum of elderly
DC Field | Value | Language |
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dc.contributor.author | Sohn, Ji-Hoon | - |
dc.contributor.author | So, Jung On | - |
dc.contributor.author | Hong, Hyun Joo | - |
dc.contributor.author | Kim, Jong Won | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Nam, Eunjoo | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Mook-Jung, Inhee | - |
dc.contributor.author | Ha, Hee Jin | - |
dc.contributor.author | Kim, Hee | - |
dc.contributor.author | Na, Duk Ryul | - |
dc.date.accessioned | 2012-06-26T06:48:40Z | - |
dc.date.available | 2012-06-26T06:48:40Z | - |
dc.date.issued | 2009-01 | - |
dc.identifier.citation | FRONTIERS IN BIOSCIENCE; Vol.14 ; 3879-3883 | ko_KR |
dc.identifier.issn | 1093-9946 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77465 | - |
dc.description.abstract | Alzheimer`s disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affinity purification method. The purified autoantibody recognized A-beta deposits in the brain of aged Tg2676 mice, an animal model of AD. The serum levels of anti-A-beta autoantibody correlated inversely with age in both AD patients and control non-demented elderly subjects. Furthermore, the levels were significantly lower in AD patients compared with the age-matched control subjects. It is the first time to show the identification of endogenous anti-A-beta autoantibody in human serum and suggesting that serum levels of anti-A-beta autoantibody might be a good biomarker for AD patients. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | FRONTIERS IN BIOSCIENCE INC | ko_KR |
dc.subject | Beta-Amyloid Peptide | ko_KR |
dc.subject | Anti- A-beta | ko_KR |
dc.subject | Aging | ko_KR |
dc.subject | Alzheimer`s disease | ko_KR |
dc.subject | autoantibody | ko_KR |
dc.title | Identification of autoantibody against beta-amyloid peptide in the serum of elderly | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 손지훈 | - |
dc.contributor.AlternativeAuthor | 소정온 | - |
dc.contributor.AlternativeAuthor | 홍현주 | - |
dc.contributor.AlternativeAuthor | 김종원 | - |
dc.contributor.AlternativeAuthor | 나덕렬 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 김희 | - |
dc.contributor.AlternativeAuthor | 남은주 | - |
dc.contributor.AlternativeAuthor | 하희진 | - |
dc.contributor.AlternativeAuthor | 김영호 | - |
dc.contributor.AlternativeAuthor | 정인희 | - |
dc.identifier.doi | 10.2735/3496 | - |
dc.citation.journaltitle | FRONTIERS IN BIOSCIENCE | - |
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dc.description.tc | 7 | - |
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