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Efficacy of an Injectable Thermosensitive Gel on Postoperative Adhesion in Rat Model

Cited 4 time in Web of Science Cited 2 time in Scopus
Authors
Ahn, Hye Seong; Lee, Hyuk-Joon; Yoo, Moon-Won; Jeong, Sang-Ho; Kim, Woo-Ho; Yang, Han-Kwang; Song, Soo-Chang; Han, Tae-Su
Issue Date
2010-10
Publisher
KOREAN SURGICAL SOCIETY
Citation
JOURNAL OF THE KOREAN SURGICAL SOCIETY; Vol.79 4; 239-245
Keywords
Postoperative adhesionIschemic button modelAntiadhesive barrierThermosensitive polymer
Abstract
Purpose: For easy application to targeted area or in laparoscopic surgery, proper injectable antiadhesive agents are needed. The efficacy of two injectable antiadhesive agents-the thermosensitive poly (organophosphazene) hydrogel (Gel group) and a mixed solution of hyaluronate and carboxymethyl cellulose (Guardix-sol (R), Hanmi Medicare, Korea; Gd group) were compared with that of a positive control (one established membranous agent [Interceed (R), Johnson & Johnson, USA; IC group]) and negative control (phosphate buffered saline, control group). Methods: Eight ischemic buttons were created on both sides of the peritoneum in twenty-four male Sprague Dawley rats. Each of the solutions, or membrane agent was applied before closing of the wound according to groups (six rats per group). Two rats in the IC group were excluded because of death or intraoperative bleeding. Animals were sacrificed at two or four weeks after surgery. The number of adhesion-forming ischemic buttons and the weight gain were analyzed. Results: The overall number of adhered ischemic buttons were 23 in the control group (n=48), 22 in the Gd group (n=48), 14 in the Gel group (n=48) and 0 in the IC group (n=32). Overall number of adhered ischemic buttons of the Gd group was not significantly different from that of the control group (P=1.000). However that of the Gel group was smaller than that of the control group, although not statistically significant (P=0.093). Conclusion: The Gel group demonstrated some possibility of having an antiadhesive effect, and the Gd group failed to show antiadhesive effect, in contrast to IC group. A large-scale preclinical study is required to verify these findings. (J Korean Surg Soc 2010;79:239-245)
ISSN
2233-7903
Language
English
URI
https://hdl.handle.net/10371/77467
DOI
https://doi.org/10.4174/jkss.2010.79.4.239
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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