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Effects of probiotic-containing yogurt on second-line triple therapy for Helicobacter pylori infection

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Issue Date
2010-09
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; Vol.25 ; A162-A162
Abstract
Introduction The adjuvant effects of probiotic-containing yogurt on
second-line triple therapy for H. pylori infection have not been
evaluated.
Methods Three hundred and thirty-seven patients with persistent H.
pylori infection, after fi rst-line triple therapy, were randomly assigned to
receive either triple therapy with (yogurt group, n = 151) or without Will
yogurt (control group, n = 186). Triple therapy consisted of moxifl oxacin,
amoxicillin, and esomeprazole for 14 days. Will yogurt contains L. acidophilus,
L. casei, B. longum, and S. thermophilus. H. pylori eradication was
evaluated by the 13C-urea breath test (UBT), and excess 13CO2/12CO2 ratio
(ECR) values were calculated. The adverse event rates were also assessed.
Results The intention-to-treat eradication rates and per-protocol eradication
rates were 66.7%/68.9% and 78.5%/86.0% in the control/yogurt
group, respectively. There was no statistical signifi cance. The adverse
event rates were 25.3%/28.5% in the control/yogurt group, respectively (P
= 0.508). The negative correlation between the pre-treatment ECR values
of the UBT and the magnitude of the decrease in the ECR value after
treatment was stronger in the yogurt group (Pearson Correlation = −0.862,
P < 0.001) than in the control group (Pearson Correlation = −0.634, P <
0.001).
Conclusions The addition of probiotic-containing yogurt to second-line
treatment might suppress H. pylori even though it was not associated with
a signifi cant eradication benefit.
ISSN
0815-9319
Language
English
URI
https://hdl.handle.net/10371/77488
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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