S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
The rate of gastric MALToma regression with H.
- Issue Date
- WILEY-BLACKWELL PUBLISHING, INC
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; Vol.25 ; A170-A170
- Objectives Helicobacter pylori eradication is widely accepted for the
initial therapy for gastric MALT lymphoma. This study assesses the remission
and relapse rate of gastric MALToma after H. pylori eradication. We
also evaluated the clinical factors which affected remission.
Methods Total 37 patients were diagnosed with gastric MALToma (May
2003–Feb 2010). Staging work-up was done with EUS, CT and bone
marrow biopsy. Treatment of MALToma was performed with H. pylori
eradication or radiotherapy or chemotherapy.
Results 29/37 (78%) patients had H. pylori infection. Patients with stage
I was 33/37 (89%). One of remainders (four) had bone marrow involvement.
Among stage I, 25 patients with H. pylori positive took eradication
therapy. 21/25 (84%) achieved remission. Even two H. pylori negative
patients showed tumor regression after eradication alone. Total regression
rate with eradication only was 23/27 (85%). Median time of remission was
127 (22–397 days). Age, sex, tumor location, H. pylori burden and severity
of polymorphonuclear leukocyte & lymphocyte infi ltration were not
related with the remission. Relapse with H. pylori reinfection occurred in
2 of 23 patients (8.7%). Median time of follow-up without lymphoma was
Conclusion These result show rate of gastric MALToma regression
(85%) with H. pylori eradication alone is higher than western studies
(75%). The further and larger studies on this higher rate will be needed.
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