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Effect of additional ecabet sodium on conventional proton-pump inhibitor-based triple therapy for H-pylori (H-pylori) eradication in Korea

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Authors
Kim, J. Y.; Lee, D. H.; Park, Y. S.; Kim, N.; Song, I. S.; Jung, H. C.
Issue Date
2010-08
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
HELICOBACTER; Vol.15 4; 344-345
Abstract
Aims: The eradication rate of proton-pump inhibitor-based
conventional triple therapy for H. pylori infection has decreased
due to increasing antibiotics resistance. Ecabet sodium is known
for bactericidal effect against H. pylori. It was reported that the
supplement of ecabet sodium on conventional triple therapy met
with good results in Asia, recently. Aim of this study was to
ascertain the efficacy of additional ecabet sodium on conventional
triple therapy for eradication of H. pylori in clinical
practice.
Methods: One hundred eleven patients (Group A) with proven
H. pylori infection received ecabet sodium with triple therapy
(20 mg of rabeprazole, 1 g of amoxicillin, 500 mg of clarithromycin
and 1 g of ecabet sodium, twice daily for 7 days). One
hundred ninety patients (Group B) received PPI- based triple
therapy (same as above, except ecabet sodium). Eradication was
evaluated 4 weeks later after completion of treatment by 13c-
urea breath testing. The Side effects were also assessed.
Results: The eradication rates were 74. 8% (83/111) in group A
and 71.1% (135/190) in group B by intention-to-treat
(p = 0.507), and 75.2% (82/109) in group A and 71.4% (132/
185) in group B by per protocol (p = 0.500). There were no
significant differences in the side effects between two treatment
groups.
Conclusions: The addition of ecabet sodium on conventional
triple therapy is found to not effectively improve eradication rate
of H. pylori in this study. The results imply ecabet sodium as
additional agent could not overcome antibiotics resistance,
which is the most important cause of failure of triple therapy.
ISSN
1083-4389
Language
English
URI
https://hdl.handle.net/10371/77504
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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