S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Clinical Characteristics of Kimura Disease in Korea
- Kang, M.; Kim, B.; Kwon, J.; Kim, T.; Lee, S.; Kim, S.; Park, H.; Kim, S.; Min, K.; Kim, Y.; Cho, S.; Chang, Y.; Kang, H.; Kim, K.; Jung, J.
- Issue Date
- JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; Vol.125 2; AB185-AB185
- RATIONALE: Kimura disease, a chronic inflammatory disorder of unknown
etiology, presents subcutaneous mass, regional lymphadenopathy,
peripheral blood eosinophilia or increased level in serum immunoglobulin
E. The purpose of this study is to investigate the clinical features of Kimura
disease in Korea.
METHODS: We consecutively enrolled 30 patients with Kimura disease
proven histologically, from January 1991 to December 2008 in Seoul
National University Hospital. Clinical course and treatment were reviewed
RESULTS: Of all patients, 26 were male (86.7%), and mean age was
26.0614.8 years. Involved sites were as follows; parotid area (n59), upper
extremity (n57), retro-auricular area (n56), submandible (n55), groin
(n54) and eyelid (n53). Eight patients had bilateral lesions. The common
symptoms were painless soft tissue swelling and pruritus. Peripheral blood
eosinophilia was observed in 27 patients (90.0%). In total 30 patients, 23
were treated with any modalities; 11 with corticosteroids, 11 with operation
and 1 with radiation. The other 7 patients were just observed without
any treatments. Among the 23 patients treated with any modalities, only 9
(4 with corticosteroids and 5 with operation) have come into the state of
complete remission (CR). The clinical courses of 21 patients who have
not been in the CR state, were variable in point of size or number of mass.
CONCLUSIONS: Although Kimura disease inKorea has variable clinical
features, a male patient with painless soft tissue swelling and peripheral blood eosinophilia can be suspected of Kimura disease. The optimal management
of Kimura disease needs further investigation.
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