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NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ARTERY CALCIFICATION SCORE BY MULTI-DETECTOR COMPUTED TOMOGRAPHY; CROSS-SECTIONAL CASE-CONTROL STUDY FROM HEALTHCARE CENTERS` NETWORK

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Authors
Kim, D.; Park, E. H.; Kim, W.; Choi, S. -Y.; Yoon, J. -H.; Lee, H. -S.; Cho, S. -H.; Kim, Y. J.
Issue Date
2010
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF HEPATOLOGY; Vol.52 ; S145-S146
Abstract
Background and Aims: Non-alcoholic Fatty Liver Disease (NAFLD)
is known to be related to risk factors of coronary heart disease
(CHD) such as dyslipidemia, diabetes, central obesity, and metabolic
syndrome. The aim of this study has been to investigate whether
NAFLD was associated with coronary artery calcification (CAC) score
which used as surrogate marker for coronary atherosclerosis.
Methods: 4,023 (mean age 56.85±9.38, male 60.7%) of 5,648
subjects in general health examination from Healthcare centers
network were enrolled without known liver disease (alcoholic,
HBV, HCV, other hepatitis history) and history or symptom of
ischemic heart disease from 2004 to 2008. NAFLD was diagnosed
by typical sonographic findings in the subjects with <20 gram/day
alcohol consumption, based on questionnaire. CAC was evaluated by
Agaston method with multi-detector computed tomography. CAC
score was grouped into two categories over 2 sets of cut points:
CAC prevalence (over 0), 0 to 100 and >100. Clinical characteristics
included sex, age, BMI, waist circumference (WC), AST, ALT, total
cholesterol, HDL cholesterol, triglycerides (TG), and glucose.
Results: In our study population, CAC prevalence (over 0) was in
1,286 of 4,023 (32.0%) and moderate-severe CAC score (>100) was
observed in 434 of 4,023 (10.8%). CAC was significantly associated
with age, sex, BMI, WC, ALT, TG, HDL and with increased odds
of diabetes, hypertension, metabolic syndrome, and severity of
NAFLD. CAC prevalence showed positive relationship with NAFLD
(OR 1.36, 95% CI 1.15–1.59, p < 0.0001) and moderate-severe CAC
score showed also positive association with NAFLD (OR 1.28, 955 CI 1.012–1.61, p = 0.039). Multivariate regression analysis showed
that CAC score was associated with male sex (OR 2.73), Age (<50 yr
reference; 50–59 yr OR 3.75; 60–69 yr OR 8.42; over 70 yr OR 21.38),
diabetes (OR 1.39), hypertension (OR 1.79), current smoker (OR 1.42)
and presence of NAFLD (OR 1.36).
Conclusions: Patients with NAFLD are at high risk of coronary
atherosclerosis regardless of individuals traits of metabolic
syndrome and classical cardiovascular risk factors. Detection of
NAFLD should alert to the existence of an increased cardiovascular
risk.
ISSN
0168-8278
Language
English
URI
https://hdl.handle.net/10371/77536
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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