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Efficacy of artesunate and artemether against Clonorchis sinensis in rabbits

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Kim, Tae Im; Yoo, Won Gi; Hong, Sung-Tae; Li, Shunyu; Hong, Sung-Jong; Keiser, Jennifer
Issue Date
2009-12
Publisher
SPRINGER
Citation
PARASITOLOGY RESEARCH; Vol.106 1; 153-156
Abstract
Artesunate and artemether display promising clonorchicidal properties in rats. In this study, we assessed the efficacy of artesunate and artemether against Clonorchis sinensis in rabbits. Rabbits were each fed with 300 C. sinensis metacercariae. At day 28 postinfection, the rabbits were administered oral artesunate at doses of 7.5-120 mg/kg and oral artemether of 15-120 mg/kg. Two groups of rabbits were treated with single oral praziquantel at 75 and 150 mg/kg. Untreated rabbits served as controls. Fourteen days after treatment, all rabbits were sacrificed, and C. sinensis adults were collected from the bile ducts and counted. At the highest doses tested (120 mg/kg) artesunate and artemether achieved statistical significant worm burden reductions of 88.8% and 67.2%, respectively. These rates were lower than worm burden reductions observed with praziquantel (88% and 100%, respectively). It is suggested that artesunate and artemether have moderate anthelminthic efficacy against C. sinensis in rabbits.
ISSN
0932-0113
Language
English
URI
http://hdl.handle.net/10371/77537
DOI
https://doi.org/10.1007/s00436-009-1641-4
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College of Medicine/School of Medicine (의과대학/대학원)Parasitology and Tropical Medicine (기생충학전공)Journal Papers (저널논문_기생충학전공)
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