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PUTATIVE ASSOCIATION OF DNA METHYLTRANSFERASE 1 (DNMT1) POLYMORPHISM WITH RISK OF HUMAN HEPATOCELLULAR CARCINOMA AMONG CHRONIC HBV PATIENTS

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Authors
Chun, J. -Y.; Bae, J. S.; Park, T. J.; Kim, J. Y.; Cheong, H. S.; Kim, J. S.; Kim, H. Y.; Lee, J. -H.; Kim, Y. J.; Shin, H. D.; Lee, H. -S.; Chung, G. E.; Hwang, S. Y.; Yu, S. J.; Park, B. L.
Issue Date
2010
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF HEPATOLOGY; Vol.52 ; S279-S279
Abstract
Background: DNA methyltransferase (DNMT) 1 is a key enzyme
responsible for the DNA methylation, which occurs often in
CpG islands near regulatory regions of genes and affects the
transcription of specific genes. In this study, we examined possible
genetic association of DNMT1 polymorphisms with HBV clearance
and the risk of hepatocellular carcinoma (HCC).
Methods: Five common polymorphic sites were selected,
considering their allele frequencies, haplotype-tagging status and
LDs for genotyping in larger-scale subjects (n = 1,093).
Result: Statistical analysis demonstrated that two intron
polymorphisms, DNMT1 +34542G>C and DNMT1 +38565G>T,
showed significant association with the resolution of HBV infection
in the co-dominant model (OR = 1.30, P = 0.005, Pcorr = 0.03),
and co-dominant/recessive model (OR = 1.34–1.74, P = 0.002–0.004,
Pcorr = 0.01–0.03), respectively.
Conclusion: These results suggest that two intron polymorphisms,
DNMT1 +34542G>C and DNMT1 +38565G>T, might be related with
HBV clearance.
ISSN
0168-8278
Language
English
URI
https://hdl.handle.net/10371/77538
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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