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Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis

Cited 3 time in Web of Science Cited 4 time in Scopus
Authors
Chung, Byung-Suk; Lee, Jeong-Keun; Choi, Min-Ho; Hong, Sung-Tae; Choi, Dongil; Park, Myoung Hee
Issue Date
2009-06
Publisher
KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
Citation
KOREAN JOURNAL OF PARASITOLOGY; Vol.47 2; 145-151
Keywords
Clonorchis sinensisbile ductfibrosissingle nucleotide polymorphismIL-10TNF-alphaTGF-beta 1IFN-gamma
Abstract
This study examined the association of cytokine gene polymorphisms with intrahepatic bile duct wall fibrosis in human clonorchiasis. A total of 240 residents in Heilongjiang, China underwent ultrasonography, blood sampling, and stool examination. Single nucleotide polymorphism (SNP) sites for IFN-gamma (+874 T/A), IL-10 (-1,082 G/A, -819 C/T, -592 C/A), TNF-alpha (-308 G/A), and TGF-beta 1 (codon 10 T/C, codon 25 G/C) genes were observed with the TaqMan allelic discrimination assay. No significant correlation was observed between individual cytokine gene polymorphisms and intrahepatic duct dilatation (IHDD). Among individuals with clonorchiasis of moderate intensity, the incidence of IHDD was high in those with IFN-gamma intermediate-producing genotype, +874AT (80.0%, P = 0.177), and in those with TNF-alpha low-producing genotype, -308GG (63.0%, P = 0.148). According to the combination of IFN-gamma and TNF-alpha genotypes, the risks for IHDD could be stratified into high (intermediate-producing IFN-gamma and low producing TNF-alpha), moderate, and low (low-producing IFN-gamma and high producing TNF-alpha) risk groups. The incidence of IHDD was significantly different among these groups (P = 0.022): 88.9% (odds ratio, OR = 24.0) in high, 56.5% (OR = 3.9) in moderate, and 25.0% (OR = 1) in low risk groups. SNP of IFN-gamma and TNF-alpha genes may contribute to the modulation of fibrosis in the intrahepatic bile duct wall in clonorchiasis patients.
ISSN
0023-4001
Language
English
URI
https://hdl.handle.net/10371/77542
DOI
https://doi.org/10.3347/kjp.2009.47.2.145
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College of Medicine/School of Medicine (의과대학/대학원)Parasitology and Tropical Medicine (기생충학전공)Journal Papers (저널논문_기생충학전공)
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