S-Space College of Medicine/School of Medicine (의과대학/대학원) Preventive Medicine (예방의학전공) Journal Papers (저널논문_예방의학전공)
Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk
- Han, Wonshik; Kang, So Young; Kang, Daehee; Park, Sue K.; Kim, Ho; Noh, Dong-Young; Park, Ae Kyung; Lee, Ji-Young
- Issue Date
- SPANDIDOS PUBL LTD
- ONCOLOGY REPORTS; Vol.23 3; 763-769
- We sought to identify genes and polymorphisms associated with breast cancer risk among Korean women using Multiplex genotyping. The SNPs (n=1536) of 264 candidate genes were genotyped using the Illumina Golden Gate (TM) assay. These genes are involved in the pathways controlling apoptosis/anti-apoptosis, the immune and inflammatory responses, cytokines, DNA repair, cell adhesion, and cell cycle/proliferation. Breast cancer cases (n=209) were recruited front Seoul National University Hospital. Age-matched control subjects (n=209) were selected from a health examinees cohort. Gene-based and SNP-based tests were performed. The final analysis includes 117 cases and 164 controls with 1107 SNPs in 232 genes. Gene-based analyses showed that IL1A, TNFRSF10B, TNFRSF1B, ICAM, and TNFSF9 were significantly associated with breast cancer risk (p<0.01). ILIA was the most significant gene associated with breast cancer risk [p for likelihood ratio test, I degree of freedom (df)=6x10(-7); FDR-adjusted p-value, 1 df=4x10(-4), 2df=0.0071, respectively]. Individual SNP-based analyses revealed that the rare allele of the ILIA SNP rs2856836, Ex7-592T -> C, was strongly associated with breast cancer risk (FDR-adjusted p-value, 1 df=0.0027, 2df=0.0162). This SNP was found to increase risk for breast cancer [odds ratio (OR)=2.88, 95% confidence interval (CI)= 1.58-5.27 for heterozygote and OR=8.17, 95% CI=2.23-29.99 for rare homozygote]. In summary, we identified a common genetic variant in ILIA strongly associated with breast cancer risk.
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