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CD4+T-CELL-DEPENDENT GOBLET CELL PROLIFERATION AND EXPULSION OF GYMNOPHALLOIDES SEOI FROM THE INTESTINE OF C57BL/6 MICE
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guk, Sang-Mee | - |
dc.contributor.author | Lee, Jun-Haeng | - |
dc.contributor.author | Kim, Hyo-Jin | - |
dc.contributor.author | Kim, Won-Hee | - |
dc.contributor.author | Chai, Jong-Yil | - |
dc.contributor.author | Shin, Eun-Hee | - |
dc.date.accessioned | 2012-06-27T04:57:55Z | - |
dc.date.available | 2012-06-27T04:57:55Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | JOURNAL OF PARASITOLOGY; Vol.95 3; 581-590 | ko_KR |
dc.identifier.issn | 0022-3395 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77564 | - |
dc.description.abstract | Mechanisms for the spontaneous worm expulsion from the host intestine are not well understood in gastrointestinal trematode models. We studied the role of CD4+ T-helper cells in mediating goblet cell hyperplasia and expulsion of Gymnophalloides seoi from the intestines of C57BL/6 (resistant) and ICR (susceptible) mice. C57BL/6 mice expelled all G. seoi. worms within 4 days post-infection (PI), while ICR mice did not completely expel worms until day 7 PI. This difference in worm expulsion was associated with high numbers of mucosal goblet cells in C57BL/6 mice along with alteration of the mucin quality, with changes in the terminal sugar chain and high levels of IL-4 and IL-5 mRNA expression in mesenteric lymph nodes. Adoptive transfer Of mucosal CD4+ T-helper cells to syngeneic mice elicited strong goblet cell hyperplasia and a notably accelerated worm expulsion. However, this T-helper cell transfer had no relationship with the alteration of mucin quality. The results showed that CD4+ T-helper cells play an important role as a mediator of goblet cell hyperplasia, but not for functional activation of goblet cells. It is Suggested that both T-cell dependent and independent mechanisms operate for expulsion of G. seoi front the mouse intestine. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC PARASITOLOGISTS | ko_KR |
dc.title | CD4+T-CELL-DEPENDENT GOBLET CELL PROLIFERATION AND EXPULSION OF GYMNOPHALLOIDES SEOI FROM THE INTESTINE OF C57BL/6 MICE | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 국상미 | - |
dc.contributor.AlternativeAuthor | 이준행 | - |
dc.contributor.AlternativeAuthor | 김효진 | - |
dc.contributor.AlternativeAuthor | 김원희 | - |
dc.contributor.AlternativeAuthor | 신은희 | - |
dc.contributor.AlternativeAuthor | 채종일 | - |
dc.identifier.doi | 10.1645/GE-1807.1 | - |
dc.citation.journaltitle | JOURNAL OF PARASITOLOGY | - |
dc.description.tc | 4 | - |
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