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Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells

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dc.contributor.authorLee, Jeong-Hoon-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorYu, Su Jong-
dc.contributor.authorChung, Goh Eun-
dc.contributor.authorKim, Hwi Young-
dc.contributor.authorChoi, Dae Hee-
dc.contributor.authorKim, Yoon Jun-
dc.contributor.authorLee, Hyo-Suk-
dc.contributor.authorKim, Chung Yong-
dc.contributor.authorMyung, Sun Jung-
dc.contributor.authorKim, Bo Hyun-
dc.contributor.authorJung, Eun Uk-
dc.date.accessioned2012-06-27T06:29:00Z-
dc.date.available2012-06-27T06:29:00Z-
dc.date.issued2010-09-28-
dc.identifier.citationCANCER LETTERS; Vol.295 2; 229-235ko_KR
dc.identifier.issn0304-3835-
dc.identifier.urihttps://hdl.handle.net/10371/77603-
dc.description.abstractHypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.ko_KR
dc.description.sponsorshipThis study was funded by the Korea Health 21 R&D Project
(#0412-CR01-0704-0001). We declare that we have no
conflict of interest for this study.		ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectCellular retinoic acid binding protein-IIko_KR
dc.subjectHepatocellular carcinomako_KR
dc.subjectRetinoic acidko_KR
dc.subjectApoptosisko_KR
dc.subjectHypoxiako_KR
dc.titleRetinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이정훈-
dc.contributor.AlternativeAuthor윤정환-
dc.contributor.AlternativeAuthor유수종-
dc.contributor.AlternativeAuthor정고은-
dc.contributor.AlternativeAuthor정은욱-
dc.contributor.AlternativeAuthor김휘영-
dc.contributor.AlternativeAuthor김보현-
dc.contributor.AlternativeAuthor최대희-
dc.contributor.AlternativeAuthor명선정-
dc.contributor.AlternativeAuthor김윤준-
dc.contributor.AlternativeAuthor김청용-
dc.contributor.AlternativeAuthor이효석-
dc.identifier.doi10.1016/j.canlet.2010.03.005-
dc.citation.journaltitleCANCER LETTERS-
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