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Salivary chemokine levels in patients with primary Sjogren`s syndrome

Cited 35 time in Web of Science Cited 32 time in Scopus
Authors
Lee, Yun Jong; Scofield, Robert H.; Hyon, Joon Young; Yun, Pil-Young; Lee, Eun Young; Song, Yeong Wook; Lee, Eun Bong; Lee, Hyo-Jung
Issue Date
2010-09
Publisher
OXFORD UNIV PRESS
Citation
RHEUMATOLOGY; Vol.49 9; 1747-1752
Keywords
Sjogren`s syndromeSiccaSalivaChemokine
Abstract
Methods. Unstimulated and stimulated whole saliva samples were obtained from pSS patients (n = 30) and age- and gender-matched patients with non-SS sicca (n = 30) and non-sicca healthy controls (n = 25). Salivary CCL2, CCL3, CCL4, CXCL8 and CXCL10 levels were measured using a Luminex bead-based multiplex assay. Results. Patients with pSS had significantly different distributions of salivary CCL3 (P = 0.0001 by the Kruskal-Wallis test), CCL4 (P < 0.00001), CXLC8 (P < 0.0001) and CXCL10 (P < 0.05) levels in unstimulated saliva and all chemokine levels in stimulated saliva when compared with non-SS sicca and non-sicca controls. In comparison with chemokine production rate, the CXCL8 and CXCL10 production rates were significantly higher in pSS than in non-SS sicca controls (P < 0.01 by the Mann-Whitney test). Logistic regression analyses revealed that salivary CXCL8 (P < 0.05) and CXCL10 (P < 0.05) were the significant discriminating chemokines between the pSS and non-SS sicca groups. Although CXCL8 and CXCL10 levels were not correlated with the focus scores, CXCL8 and CXCL10 levels were significantly associated with salivary gland dysfunction. Conclusion. These results support the notion that CXCL8 or CXCL10 chemokine plays a role in the pathogenesis of pSS.
ISSN
1462-0324
Language
English
URI
http://hdl.handle.net/10371/77606
DOI
https://doi.org/10.1093/rheumatology/keq121
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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