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HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Sae-Hoon | - |
dc.contributor.author | Kim, Myunghwa | - |
dc.contributor.author | Lee, Kyung Wha | - |
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Park, Heung-Woo | - |
dc.contributor.author | Jee, Young-Koo | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.accessioned | 2012-06-27T07:11:35Z | - |
dc.date.available | 2012-06-27T07:11:35Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | PHARMACOGENOMICS; Vol.11 6; 879-884 | ko_KR |
dc.identifier.issn | 1462-2416 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77623 | - |
dc.description.abstract | Aims: The carbonic anhydrase inhibitor methazolamide infrequently causes Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). An association between these diseases and the HLA-B59 serotype has been suggested in case reports. This study examined the disease-associated B*59 allele and investigated the association of these diseases with other HLA class I alleles. Methods: We performed high-resolution HLA-A, -B and -C genotyping in five patients with methazolamide-induced SJS/TEN using a PCR-sequencing-based typing method and analyzed the association between HLA-class I alleles and occurrence of methazolamide-induced SJS/TEN. Results: B*5901 and Cw*0102 alleles were observed in all patients and A*2402 was observed in four patients. The B*5901 allele showed the strongest association with methazolamide-induced SJS/TEN (p < 0.001; odds ratio: 249.8; 95% Cl: 13.4-4813.5), followed by Cw*0102 (p = 0.004; odds ratio: 22.1; 95% Cl: 1.2-414.3), when compared with the general population as a control. The frequency of the patients carrying B*5901, Cw*0102 and A*2402 simultaneously was significantly higher than that in the general population (p < 0.001; odds ratio: 110.1; 95% Cl: 11.7-1038.6). Conclusion: A strong association was observed between HLA-B*5901 and methazolamide-induced SJS/TEN in Korean patients. HLA-B*5901 may be a useful screening marker for predicting methazolamide-induced SJS/TEN in patients of Korean and Japanese ancestry. | ko_KR |
dc.description.sponsorship | This study was supported by a grant of the Korean
Health 21 R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (A030001). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | FUTURE MEDICINE LTD | ko_KR |
dc.subject | carbonic anhydrase inhibitor | ko_KR |
dc.subject | toxic epidermal necrolysis | ko_KR |
dc.subject | human leukocyte antigen | ko_KR |
dc.subject | methazolamide | ko_KR |
dc.subject | Stevens-Johnson syndrome | ko_KR |
dc.title | HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김새훈 | - |
dc.contributor.AlternativeAuthor | 김명화 | - |
dc.contributor.AlternativeAuthor | 이경화 | - |
dc.contributor.AlternativeAuthor | 김상헌 | - |
dc.contributor.AlternativeAuthor | 강혜련 | - |
dc.contributor.AlternativeAuthor | 박흥우 | - |
dc.contributor.AlternativeAuthor | 지영구 | - |
dc.identifier.doi | 10.2217/PGS.10.54 | - |
dc.citation.journaltitle | PHARMACOGENOMICS | - |
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dc.description.tc | 2 | - |
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