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CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Yim | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Kim, Seung-Ki | - |
dc.contributor.author | Phi, Ji-Hoon | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Cho, Byung-Kyu | - |
dc.contributor.author | Wang, Kyu-Chang | - |
dc.contributor.author | Kim, Jin-Hyun | - |
dc.date.accessioned | 2012-06-27T07:11:36Z | - |
dc.date.available | 2012-06-27T07:11:36Z | - |
dc.date.issued | 2009-06 | - |
dc.identifier.citation | ONCOLOGY REPORTS; Vol.21 6; 1413-1419 | ko_KR |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77624 | - |
dc.description.abstract | CKD-602 7-[2-(N-isopropylamino)ethyl]-(20S)camptothecin, belotecan) is a synthetic water-soluble camptothecin derivative and topoisornerase inhibitor that has been shown to have clinical anticancer effect against ovarian and lung cancer. We studied its anticancer effects oil four human glioma cell lines, U87 MG, U343 MG, U251 MG and LN229. Cell viability was quantified by a modified 2-(2-methoxy-4-methoxy)-3-(4-nitropheyl)-5-(2,4-disulfophellyl) -2H-tetrazolium, monosodium salt and significant time- and dose-dependent cytotoxicity was observed in all cell lines. Susceptibility to CKD-602 at 48 h after treatment varied among the four cell lines and their IC(50) value was as follows: 9.07 nM (95% CI 0.18-37.42) for LN229, 14.57 nM (95% Cl 0.86-47.33) for U251 MG, 29.13 nM (95% CI 0.35-101.23) for U343 MG, and 84.66 nM (95% CI 34.63-148.25) for U87 MG. CKD-602 induced cell cycle arrest at G2 phase and produced antiproliferative activity and apoptosis in all cell lines. Thus, CKD-602 showed a significant anticancer effect on glioma cells in vitro and is a promising candidate for further studies on malignant gliomas. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SPANDIDOS PUBL LTD | ko_KR |
dc.subject | belotecan | ko_KR |
dc.subject | camptothecin analogue | ko_KR |
dc.subject | CKD-602 | ko_KR |
dc.subject | topoisomerase 1 inhibitor | ko_KR |
dc.subject | malignant glioma | ko_KR |
dc.title | CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김영임 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김승기 | - |
dc.contributor.AlternativeAuthor | 피지훈 | - |
dc.contributor.AlternativeAuthor | 김진현 | - |
dc.contributor.AlternativeAuthor | 김채용 | - |
dc.contributor.AlternativeAuthor | 왕규창 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.identifier.doi | 10.3892/or_00000369 | - |
dc.citation.journaltitle | ONCOLOGY REPORTS | - |
dc.description.citedreference | Morandi E, 2008, MOL CANCER, V7, DOI 10.1186/1476-4598-7-66 | - |
dc.description.citedreference | Djuzenova CS, 2008, CANCER BIOL THER, V7, P364 | - |
dc.description.citedreference | Feun LG, 2007, J NEURO-ONCOL, V82, P177, DOI 10.1007/s11060-006-9261-7 | - |
dc.description.citedreference | Vredenburgh JJ, 2007, CLIN CANCER RES, V13, P1253, DOI 10.1158/1078-0432.CCR-06-2309 | - |
dc.description.citedreference | Klautke G, 2006, J NEURO-ONCOL, V77, P199, DOI 10.1007/s11060-005-9028-6 | - |
dc.description.citedreference | Gomez-Manzano C, 2006, CLIN CANCER RES, V12, P556, DOI 10.1158/1078-0432.CCR-05-1892 | - |
dc.description.citedreference | JUNG JY, 2006, CANC RES TREAT, V38, P159 | - |
dc.description.citedreference | Stupp R, 2005, NEW ENGL J MED, V352, P987 | - |
dc.description.citedreference | Michielin O, 2004, LANCET ONCOL, V5, P322 | - |
dc.description.citedreference | Reardon DA, 2004, NEURO-ONCOLOGY, V6, P134 | - |
dc.description.citedreference | Wang YL, 2004, ONCOGENE, V23, P1283, DOI 10.1038/sj.onc.1207244 | - |
dc.description.citedreference | Friedman HS, 2003, CANCER, V97, P2359, DOI 10.1002/cncr.11305 | - |
dc.description.citedreference | Raymond E, 2003, ANN ONCOL, V14, P603, DOI 10.1093/annonc/mdg159 | - |
dc.description.citedreference | Kim EJ, 2003, ARZNEIMITTEL-FORSCH, V53, P272 | - |
dc.description.citedreference | SONG Y, 2003, P AM SOC CLIN ONCOL, V22 | - |
dc.description.citedreference | KIM HK, 2002, P AM SOC CLIN ONCOL, V21 | - |
dc.description.citedreference | MATHIJSSEN RH, 2002, CURR CANCER DRUG TAR, V2, P103 | - |
dc.description.citedreference | Lee JH, 2000, ANN NY ACAD SCI, V922, P324 | - |
dc.description.citedreference | JOSSON E, 2000, EUR J CANCER, V36, P2120 | - |
dc.description.citedreference | Thompson J, 1999, CLIN CANCER RES, V5, P3617 | - |
dc.description.citedreference | Ishii N, 1999, BRAIN PATHOL, V9, P469 | - |
dc.description.citedreference | KOLIMANNSBERGER C, 1999, ONCOLOGY, V56, P1 | - |
dc.description.citedreference | Lee JH, 1998, ARCH PHARM RES, V21, P581 | - |
dc.description.citedreference | LEE JH, 1998, P AM ASSOC CANC RES, V39, P303 | - |
dc.description.citedreference | JANSS AJ, 1998, EXP CELL RES, V243, P2 | - |
dc.description.citedreference | OConnor PM, 1997, CANCER RES, V57, P4285 | - |
dc.description.citedreference | Nakatsu S, 1997, CANCER CHEMOTH PHARM, V39, P417 | - |
dc.description.citedreference | Bissery MC, 1996, ANTI-CANCER DRUG, V7, P437 | - |
dc.description.citedreference | Jew SP, 1996, BIOORG MED CHEM LETT, V6, P845 | - |
dc.description.citedreference | MATSUMOTO Y, 1993, J SURG ONCOL, V53, P97 | - |
dc.description.citedreference | FASSBERG J, 1992, J PHARM SCI, V81, P676 | - |
dc.description.citedreference | DARPA P, 1990, CANCER RES, V50, P6919 | - |
dc.description.citedreference | MUGGIA FM, 1972, CANCER CHEMOTH REP 1, V56, P515 | - |
dc.description.citedreference | MOERTEL CG, 1972, CANCER CHEMOTH REP 1, V56, P95 | - |
dc.description.citedreference | GOTTLIEB JA, 1970, CANCER CHEMOTH REP 1, V54, P461 | - |
dc.description.citedreference | WALL ME, 1966, J AM CHEM SOC, V88, P3888 | - |
dc.description.tc | 5 | - |
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