S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
H. pylori Infection is Negatively Associated with Reflux Esophagitis: A Cross-Sectional Case-Control Study of 5616 Health Check-up Koreans
- Chung, S.; Choi, J.; Kim, D.; Jung, H.; Song, I.
- Issue Date
- WILEY-BLACKWELL PUBLISHING, INC
- HELICOBACTER; Vol.14 4; 368-368
- Background: The relationship between Helicobacter pylori infection
and gastroesophageal reflux disease remains controversial.
Aim: To investigate this relationship in a large Korean populationbased
Methods: A cross-sectional case–control study of 5616 health
check-up subjects undergoing upper gastrointestinal endoscopy
was conducted (2808 cases with reflux esophagitis versus age- and
sex-matched controls). Helicobacter pylori infection was determined
by measuring anti-H. pylori IgG.
Results: The prevalence of H. pylori infection was significantly
lower in subjects with reflux esophagitis than in controls (38.4%
vs 58.2%, p < .001). After adjusting for the effects of smoking,
alcohol, waist circumference, and body mass index H. pylori
infection is negatively associated with reflux esophagitis [odds
ratio (OR) 0.44, 95% confidence interval (CI) 0.39–0.49]. There
was significant inverse correlation between the severity of esphagitis
and the prevalence of H. pylori infection. Subjects infected with
H. pylori showed a significant increase in the risk of gastric atrophy
(OR 3.22, 95% CI 2.79–3.70).
Conclusions: H. pylori seropositivity was independently associated
with the reduced risk for reflux esophagitis and correlates with
the milder grade of esophagitis in Korean population, which
suggest that H. pylori infection may play an inhibitory role for
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