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Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice

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dc.contributor.authorYang, Jae-Seong-
dc.contributor.authorKim, Jin Taek-
dc.contributor.authorJeon, Jouhyun-
dc.contributor.authorPark, Ho Sun-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorKim, Sanguk-
dc.contributor.authorCho, Young Min-
dc.contributor.authorLee, Hong Kyu-
dc.contributor.authorKang, Gyeong Hoon-
dc.date.accessioned2012-06-27T07:45:58Z-
dc.date.available2012-06-27T07:45:58Z-
dc.date.issued2010-11-05-
dc.identifier.citationPLOS ONE; Vol.5 11; -ko_KR
dc.identifier.issn1932-6203-
dc.identifier.urihttps://hdl.handle.net/10371/77638-
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is highly prevalent and associated with considerable morbidities. Unfortunately, there is no currently available drug established to treat NAFLD. It was recently reported that intraperitoneal administration of taurine-conjugated ursodeoxycholic acid (TUDCA) improved hepatic steatosis in ob/ob mice. We hereby examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice. We administered TUDCA to ob/ob mice at a dose of 500 mg/kg twice a day by gastric gavage for 3 weeks. Body weight, glucose homeostasis, endoplasmic reticulum (ER) stress, and hepatic gene expression were examined in comparison with control ob/ob mice and normal littermate C57BL/6J mice. Compared to the control ob/ob mice, TUDCA treated ob/ob mice revealed markedly reduced liver fat stained by oil red O (44.2 +/- 5.8% vs. 21.1 +/- 10.4%, P<0.05), whereas there was no difference in body weight, oral glucose tolerance, insulin sensitivity, and ER stress. Microarray analysis of hepatic gene expression demonstrated that oral TUDCA treatment mainly decreased the expression of genes involved in de novo lipogenesis among the components of lipid homeostasis. At pathway levels, oral TUDCA altered the genes regulating amino acid, carbohydrate, and drug metabolism in addition to lipid metabolism. In summary, oral TUDCA treatment decreased hepatic steatosis in ob/ob mice by cooperative regulation of multiple metabolic pathways, particularly by reducing the expression of genes known to regulate de novo lipogenesis.ko_KR
dc.language.isoenko_KR
dc.publisherPUBLIC LIBRARY SCIENCEko_KR
dc.titleChanges in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Miceko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor양재성-
dc.contributor.AlternativeAuthor김진택-
dc.contributor.AlternativeAuthor전주현-
dc.contributor.AlternativeAuthor박호선-
dc.contributor.AlternativeAuthor강경훈-
dc.contributor.AlternativeAuthor박경수-
dc.contributor.AlternativeAuthor이홍규-
dc.contributor.AlternativeAuthor김상욱-
dc.contributor.AlternativeAuthor조영민-
dc.identifier.doi10.1371/journal.pone.0013858-
dc.citation.journaltitlePLOS ONE-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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