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Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons

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dc.contributor.authorKang, Jung Mook-
dc.contributor.authorKim, Nayoung-
dc.contributor.authorKim, Joo-Hyon-
dc.contributor.authorOh, Euichaul-
dc.contributor.authorLee, Byoung Hwan-
dc.contributor.authorPark, Ji Hyun-
dc.contributor.authorNam, Ryoung Hee-
dc.contributor.authorLee, Hye Seung-
dc.contributor.authorJung, Hyun Chae-
dc.contributor.authorSong, In Sung-
dc.contributor.authorKim, Joo Sung-
dc.contributor.authorLee, Hee Eun-
dc.contributor.authorLee, Mi Kyoung-
dc.contributor.authorShin, Cheol Min-
dc.contributor.authorLee, Bong-Yong-
dc.date.accessioned2012-06-27T07:53:46Z-
dc.date.available2012-06-27T07:53:46Z-
dc.date.issued2010-11-
dc.identifier.citationAMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY; Vol.299 5; G1147-G1153ko_KR
dc.identifier.issn0193-1857-
dc.identifier.urihttp://hdl.handle.net/10371/77643-
dc.description.abstractKang JM, Kim N, Kim J, Oh E, Lee B, Lee BH, Shin CM, Park JH, Lee MK, Nam RH, Lee HE, Lee HS, Kim JS, Jung HC, Song IS. Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons. Am J Physiol Gastrointest Liver Physiol 299: G1147-G1153, 2010. First published August 19, 2010; doi: 10.1152/ajpgi.00218.2010.-Aging changes in the stomach lead to a decreased capacity for tissue repair in response to gastric acid. The aim of this study was to determine the mechanism associated with the increased susceptibility to injury of aging mucosa including reactive oxygen species (5), apoptosis, angiogenesis, and sensory neuron activity. Fischer 344 rats at four different ages (6, 31, 74 wk, and 2 yr of age) were studied. The connective tissue indicators [salt-soluble collagen and sulfated glycosaminoglycan (sGAG)], lipid hydroperoxide (LPO), myeloperoxidase (MPO), and hexosamine were assessed. We also evaluated the expression of early growth response-1 (Egr-1), phosphatase and tension homologue deleted on chromosome 10 (PTEN), caspase-9 (index of apoptosis), VEGF (index of angiogenesis), calcitonin gene-related peptide (CGRP, index of sensory neurons), and neuronal nitric oxide synthase (nNOS). The histological connective tissue area in the lower part of rat gastric mucosa increased with aging, with increase of salt-soluble collagen and sGAG. LPO and MPO in old rats were significantly greater than in the young rats, whereas hexosamine was significantly reduced. The old gastric mucosa had increased expression of Egr-1, PTEN, and caspase-9, whereas the VEGF, CGRP, and nNOS expression were significantly reduced. These results indicate that the lower part of rat gastric mucosa was found to be replaced by connective tissue with accumulation of oxidative products with aging. In addition, impairment of apoptosis, angiogenesis, and sensory neuron activity via the activation of Egr-1 and PTEN might increase the susceptibility of gastric mucosa to injury during aging.ko_KR
dc.description.sponsorshipThis work was supported by grant no 06-2009-032 from the Seoul National
University Bundang Hospital Research fund.
ko_KR
dc.language.isoenko_KR
dc.publisherAMER PHYSIOLOGICAL SOCko_KR
dc.subjectEgr-1ko_KR
dc.subjectCGRPko_KR
dc.subjectreactive oxygen speciesko_KR
dc.subjectlipid hydroperoxideko_KR
dc.subjectaging gastropathyko_KR
dc.subjectPTENko_KR
dc.subjectcaspase-3ko_KR
dc.subjectglycosaminoglycanko_KR
dc.titleEffect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neuronsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강정묵-
dc.contributor.AlternativeAuthor김나영-
dc.contributor.AlternativeAuthor김주현-
dc.contributor.AlternativeAuthor오의철-
dc.contributor.AlternativeAuthor이봉용-
dc.contributor.AlternativeAuthor이병환-
dc.contributor.AlternativeAuthor신철민-
dc.contributor.AlternativeAuthor박지현-
dc.contributor.AlternativeAuthor이미경-
dc.contributor.AlternativeAuthor남령희-
dc.contributor.AlternativeAuthor이희은-
dc.contributor.AlternativeAuthor이혜승-
dc.contributor.AlternativeAuthor김주성-
dc.contributor.AlternativeAuthor정현채-
dc.contributor.AlternativeAuthor송인성-
dc.identifier.doi10.1152/ajpgi.00218.2010-
dc.citation.journaltitleAMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY-
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