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류마티스 관절염의 약물치료(II): 사용중인 생물학적 제제 및 개발중인 약제
Medical treatment of rheumatoid arthritis (II): current biologic agents and newly developing drugs

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dc.contributor.author송영욱-
dc.contributor.author김진현-
dc.date.accessioned2012-06-27T08:59:39Z-
dc.date.available2012-06-27T08:59:39Z-
dc.date.issued2010-10-
dc.identifier.citationJOURNAL OF THE KOREAN MEDICAL ASSOCIATION; Vol.53 10; 880-888ko_KR
dc.identifier.issn1975-8456-
dc.identifier.urihttps://hdl.handle.net/10371/77661-
dc.description.abstractDisease-modifying antirheumatic drugs (DMARD) have been used to treat rheumatoid arthritis (RA). However, they have limited efficacy and a considerable adverse event profile. Excess production of soluble cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6, appears to mediate the chronic inflammation associated with RA. Clinical trials with targeted anticytokine biologic agents, including anti-TNF alpha antibodies (adalimumab, infliximab, golimumab, cedolizumab), anti-IL-6 receptor antibodies (tocilizumab), and the soluble tumor necrosis factor-a receptor (etanercept), have shown remarkable efficacy in the treatment of RA. In addition, costimulatory blockade (abatacept) and B cell depletion (rituximab) have been employed as important adjunctive therapies in RA. Judicious use of these agents, considering their benefits and risks, would bring the greatest benefit to RA patients. The optimal conditions for the administration and indication of these drugs are under investigation. Signal transduction is another target of newly developing drugs. Because of the development of anti-TNF therapy and other biologics, there have been great advances in the treatment of RA.ko_KR
dc.description.sponsorshipThis study was supported by a grant of the Korea
Healthcare technology R&D Project, Ministry for
Health and Welfare, Republic of Korea (A084794).
ko_KR
dc.language.isokoko_KR
dc.publisherKOREAN MEDICAL ASSOCko_KR
dc.subjectRheumatoid arthritisko_KR
dc.subjectKinase inhibitorko_KR
dc.subjectSecondary signalko_KR
dc.subjectCytokineko_KR
dc.subjectB cell depletionko_KR
dc.title류마티스 관절염의 약물치료(II): 사용중인 생물학적 제제 및 개발중인 약제ko_KR
dc.title.alternativeMedical treatment of rheumatoid arthritis (II): current biologic agents and newly developing drugsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthorSong, Yeong-Wook-
dc.contributor.AlternativeAuthorKim, Jinhyun-
dc.identifier.doi10.5124/jkma.2010.53.10.880-
dc.citation.journaltitleJOURNAL OF THE KOREAN MEDICAL ASSOCIATION-
dc.description.citedreferenceVassilopoulos D, 2010, ANN RHEUM DIS, V69, P1352, DOI 10.1136/ard.2009.127233-
dc.description.citedreferenceCohen S, 2010, CURR OPIN RHEUMATOL, V22, P330, DOI 10.1097/BOR.0b013e3283378e6f-
dc.description.citedreferenceKim YJ, 2010, J RHEUMATOL, V37, P346, DOI 10.3899/jrheum.090436-
dc.description.citedreferenceFleischmann RM, 2009, ARTHRITIS RHEUM, V60, P3225, DOI 10.1002/art.24906-
dc.description.citedreferenceChung SJ, 2009, J RHEUMATOL, V36, P2416, DOI 10.3899/jrheum.081324-
dc.description.citedreferenceKremer JM, 2009, ARTHRITIS RHEUM, V60, P1895, DOI 10.1002/art.24567-
dc.description.citedreferenceCarson KR, 2009, BLOOD, V113, P4834, DOI 10.1182/blood-2008-10-186999-
dc.description.citedreferenceDamjanov N, 2009, ARTHRITIS RHEUM, V60, P1232, DOI 10.1002/art.24485-
dc.description.citedreferenceKeystone E, 2009, ANN RHEUM DIS, V68, P216, DOI 10.1136/ard.2007.085787-
dc.description.citedreferenceCharpin C, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2868-
dc.description.citedreferenceSalliot C, 2009, ANN RHEUM DIS, V68, P25, DOI 10.1136/ard.2007.083188-
dc.description.citedreferenceMoreland LW, 2009, ANN NY ACAD SCI, V1182, P88, DOI 10.1111/j.1749-6632.2009.05072.x-
dc.description.citedreferenceMaxwell L, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007277.pub2-
dc.description.citedreferenceKUKAR M, 2009, BIOLOGICS, V3, P443-
dc.description.citedreferenceEmery P, 2008, ANN RHEUM DIS, V67, P1516, DOI 10.1136/ard.2008.092932-
dc.description.citedreferenceWeinblatt ME, 2008, ARTHRITIS RHEUM, V58, P3309, DOI 10.1002/art.23992-
dc.description.citedreferenceEmery P, 2008, LANCET, V372, P375-
dc.description.citedreferenceSmolen JS, 2008, LANCET, V371, P987-
dc.description.citedreferenceSmitten AL, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2404-
dc.description.citedreferenceKeystone E, 2007, ARTHRITIS RHEUM, V56, P3896, DOI 10.1002/art.23059-
dc.description.citedreferenceNishimoto N, 2007, ANN RHEUM DIS, V66, P1162, DOI 10.1136/ard.2006.068064-
dc.description.citedreferenceWolfe F, 2007, ARTHRITIS RHEUM, V56, P2886, DOI 10.1002/art.22864-
dc.description.citedreferenceFinckh A, 2007, ARTHRITIS RHEUM, V56, P1417, DOI 10.1002/art.22520-
dc.description.citedreferenceSONG JS, 2007, J KOREAN RHEUM ASS, V14, P1-
dc.description.citedreferenceCohen SB, 2006, ARTHRITIS RHEUM, V54, P2793, DOI 10.1002/art.22025-
dc.description.citedreferenceSetoguchi S, 2006, ARTHRITIS RHEUM, V54, P2757, DOI 10.1002/art.22056-
dc.description.citedreferenceKremer JM, 2006, ANN INTERN MED, V144, P865-
dc.description.citedreferenceBongartz T, 2006, JAMA-J AM MED ASSOC, V295, P2275-
dc.description.citedreferenceBreedveld FC, 2006, ARTHRITIS RHEUM, V54, P26, DOI 10.1002/art.21519-
dc.description.citedreferenceGenovese MC, 2005, NEW ENGL J MED, V353, P1114-
dc.description.citedreferenceGenovese MC, 2004, ARTHRITIS RHEUM, V50, P1412, DOI 10.1002/art.20221-
dc.description.citedreferenceKeystone EC, 2004, ARTHRITIS RHEUM, V50, P1400, DOI 10.1002/art.20217-
dc.description.citedreferenceKlareskog L, 2004, LANCET, V363, P675-
dc.description.citedreferenceSTCLAIR EW, 2004, ARTHRITIS RHEUM, V50, P3432-
dc.description.citedreferenceLipsky PE, 2000, NEW ENGL J MED, V343, P1594-
dc.description.citedreferenceMaini R, 1999, LANCET, V354, P1932-
dc.description.citedreference*KOR FOOD DRUG ADM, GUID TREATM LAT TUB-
dc.description.citedreferenceSTONE JH, OVERVIEW BIOL AGENTS-
dc.description.citedreference*CTR BIOL EV RES, WHAT IS BIOL PROD-
dc.description.citedreferenceCHATZIDIONYSIOU K, 2009 EULAR SCI M STO-
dc.description.tc0-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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