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CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features

Cited 32 time in Web of Science Cited 34 time in Scopus
Authors
Park, Seog-Yun; Kook, Myeong Cherl; Kim, Young Woo; Cho, Nam-Yun; Kwon, Hyeong-Ju; Kang, Gyeong Hoon; Kim, Tae-You; Jung, Namhee
Issue Date
2010-10
Publisher
SPRINGER
Citation
VIRCHOWS ARCHIV; Vol.457 4; 415-422
Keywords
CpG islandCpG island methylator phenotypeGastric cancerMethylation
Abstract
Gastric carcinoma (GC) is one of the human cancers in which promoter CpG island hypermethylation is frequently found. CpG island methylator phenotype (CIMP) refers to a subset of GCs which harbor concordant methylation of multiple promoter CpG island loci. However, little is known regarding clinicopathological features of CIMP-positive (CIMP-high) GC. Our study aimed to characterize clinicopathological features of CIMP-high GC. We analyzed 196 cases of GCs for their methylation status in 16 cancer-specific CpG island loci using MethyLight assay and arbitrarily defined CIMP-high GC as those with methylation at 13 or more CpG island loci. With exclusion of microsatellite instability-positive GC and EBV-positive GC from the analysis, CIMP-high GC (n = 10, 6.7%) demonstrated tendency toward higher cancer stage, infiltrative growth type, poor differentiation, and diffuse or mixed type of Lauren classification. CIMP-high GC showed significantly shortened survival compared with that of CIMP-negative GC. When CIMP-negative GC (methylation at 12 or less) was divided into CIMP-intermediate and CIMP-low (methylation at one or none), CIMP-low exhibited better clinical outcome than CIMP-intermediate. Hypermethylation at 14 CpG island loci or more was closely associated with poor clinical outcome and found to be an independent prognostic factor. Our findings that CIMP-high GCs were featured with characteristic clinicopathological parameters, including poor prognosis are distinct from previous studies. More extensive, large-scaled study is necessary to validate the findings of the present study.
ISSN
0945-6317
Language
English
URI
http://hdl.handle.net/10371/77662
DOI
https://doi.org/10.1007/s00428-010-0962-0
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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