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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

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dc.contributor.authorYamauchi, Toshimasa-
dc.contributor.authorHara, Kazuo-
dc.contributor.authorMaeda, Shiro-
dc.contributor.authorYasuda, Kazuki-
dc.contributor.authorHorikoshi, Momoko-
dc.contributor.authorFujita, Hayato-
dc.contributor.authorCauchi, Stephane-
dc.contributor.authorMa, Ronald C. W.-
dc.contributor.authorKubo, Michiaki-
dc.contributor.authorJorgensen, Torben-
dc.contributor.authorWitte, Daniel R.-
dc.contributor.authorAndersen, Gitte-
dc.contributor.authorShin, Hyoung Doo-
dc.contributor.authorShojima, Nobuhiro-
dc.contributor.authorIwabu, Masato-
dc.contributor.authorOkada-Iwabu, Miki-
dc.contributor.authorMaegawa, Hiroshi-
dc.contributor.authorWatada, Hirotaka-
dc.contributor.authorKawamori, Ryuzo-
dc.contributor.authorKashiwagi, Atsunori-
dc.contributor.authorTanaka, Yasushi-
dc.contributor.authorIto, Chikako-
dc.contributor.authorTai, E. Shyong-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorChan, Juliana C. N.-
dc.contributor.authorBeury, Delphine-
dc.contributor.authorSo, Wing-Yee-
dc.contributor.authorKadowaki, Takashi-
dc.contributor.authorNakamura, Yusuke-
dc.contributor.authorKamatani, Naoyuki-
dc.contributor.authorPedersen, Oluf-
dc.contributor.authorFroguel, Philippe-
dc.contributor.authorKasuga, Masato-
dc.contributor.authorHirose, Hiroshi-
dc.contributor.authorKaku, Kohei-
dc.contributor.authorSaito, Ikuo-
dc.contributor.authorOmori, Shintaro-
dc.contributor.authorOhshige, Toshihiko-
dc.contributor.authorHansen, Torben-
dc.contributor.authorSandbaek, Annelli-
dc.contributor.authorLauritzen, Torsten-
dc.contributor.authorTsunoda, Tatsuhiko-
dc.contributor.authorNg, Daniel P. K.-
dc.contributor.authorGrarup, Niels-
dc.contributor.authorNakamura, Masahiro-
dc.contributor.authorTakahashi, Atsushi-
dc.date.accessioned2012-06-28T00:17:30Z-
dc.date.available2012-06-28T00:17:30Z-
dc.date.issued2010-10-
dc.identifier.citationNATURE GENETICS; Vol.42 10; 864-869ko_KR
dc.identifier.issn1061-4036-
dc.identifier.urihttps://hdl.handle.net/10371/77677-
dc.description.abstractWe conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 x 10(-9); rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 x 10(-9)). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 x 10(-14), whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.ko_KR
dc.language.isoenko_KR
dc.publisherNATURE PUBLISHING GROUPko_KR
dc.titleA genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4Bko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor신형두-
dc.identifier.doi10.1038/ng.660-
dc.citation.journaltitleNATURE GENETICS-
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