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A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang Gyun | - |
dc.contributor.author | Song, Ho June | - |
dc.contributor.author | Choi, Il Ju | - |
dc.contributor.author | Cho, Joo Young | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Lee, Yong Chan | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Park, Byung Joo | - |
dc.contributor.author | Kim, Jae Gyu | - |
dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Jung, Hwoon-Yong | - |
dc.date.accessioned | 2012-06-28T01:12:34Z | - |
dc.date.available | 2012-06-28T01:12:34Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.citation | GUT AND LIVER; Vol.4 4; 514-517 | ko_KR |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77697 | - |
dc.description.abstract | Background/Aims: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo-controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. Methods: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow-ups (with a window of 7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. Results: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. Conclusions: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea. (Gut Liver 2010;4:514-517) | ko_KR |
dc.description.sponsorship | This study was supported by a grant from Korea College of Helicobacter and Upper Gastrointestinal Research. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | ko_KR |
dc.subject | Helicobacter pylori | ko_KR |
dc.subject | Endoscopic resection | ko_KR |
dc.subject | Iatrogenic ulcer | ko_KR |
dc.subject | Eradication | ko_KR |
dc.subject | Medical Research Collaboration Center | ko_KR |
dc.title | A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김상균 | - |
dc.contributor.AlternativeAuthor | 송호준 | - |
dc.contributor.AlternativeAuthor | 최일주 | - |
dc.contributor.AlternativeAuthor | 조주영 | - |
dc.contributor.AlternativeAuthor | 정훈용 | - |
dc.contributor.AlternativeAuthor | 금보라 | - |
dc.contributor.AlternativeAuthor | 천재희 | - |
dc.contributor.AlternativeAuthor | 이용찬 | - |
dc.contributor.AlternativeAuthor | 김재규 | - |
dc.contributor.AlternativeAuthor | 박병주 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.identifier.doi | 10.5009/gnl.2010.4.4.514 | - |
dc.citation.journaltitle | GUT AND LIVER | - |
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dc.description.tc | 0 | - |
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