S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Clinical features of eosinophilic liver abscess
- Kim, K.; Kwon, J.; Kim, S.; Kang, H.; Kim, S.; Min, K.; Kim, Y.; Cho, S.; Park, H.
- Issue Date
- WILEY-BLACKWELL PUBLISHING, INC
- ALLERGY; Vol.64 ; 154-154
- Backgroud: Eosinphilic liver abscess is
often encountered in clinical practice. Imaging
findings of eosinophilic liver abscess are
well characterized but its clinical features
are totally unknown.
Methods: Medical records of Seoul National
University Hospital in Seoul, Korea, from
July 2004 to February 2008, were retrospectively
reviewed. Eosinophilic liver abscess
was defined by typical radiologic findings on
computed tomography (CT) plus peripheral
eosinophilia (>500 ll).
Results: The incidence rate was 0.7% (257
cases/36 438 subject who underwent CT)
and medical records of 229 cases (male;
75.5%) were analyzed. Among them,
76.8% of cases were found by chance (routine
check or CT for other purposes) and
thus they were asymptomatic. The others
complained of non-specific symptoms, such
as vague abdominal pain, nausea, loose
stool, and dyspepsia. Presumptive causes
were unidentified (70.3%), malignancyassociated
(10.4%) and hypereosinophilic syndrome
(2.2%) in decreasing order. At the end
of observation periods, 63.4% of cases
without identified causes showed spontaneous
resolutions [mean time (range) from detection to resolution; 7.0 (0.3–53.0)
months] and the rests showed no progress.
Among cases without identified causes,
32.3% were treated by empirical anti-parasitic
drugs which showed no difference
in resolution rates (75.3% versus 71.2%,
P > 0.05) but showed significantly reduced
mean resolution times (10.8 versus
4.8 months, P = 0.018).
Conclusions: Eosinophilic liver abscess
without an obvious cause shows a benign
clinical course. Empirical anti-parasitic
treatment may shorten the duration of
eosinophilic liver abscess.
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