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L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes
DC Field | Value | Language |
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dc.contributor.author | Song, Young-Hwan | - |
dc.contributor.author | Cho, Hana | - |
dc.contributor.author | Ryu, Shin-Young | - |
dc.contributor.author | Yoon, Jin-Young | - |
dc.contributor.author | Noh, Chung-Il | - |
dc.contributor.author | Ho, Won-Kyung | - |
dc.contributor.author | Lee, Suk-Ho | - |
dc.contributor.author | Park, Sun-Hyun | - |
dc.date.accessioned | 2012-06-28T01:38:38Z | - |
dc.date.available | 2012-06-28T01:38:38Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY; Vol.48(4); 773-780 | ko_KR |
dc.identifier.issn | 0022-2828 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77709 | - |
dc.description.abstract | The Ca(2+)-dependent facilitation (CDF) of L-type Ca(2+) channels, a major mechanism for force-frequency relationship of cardiac contraction, is mediated by Ca(2+)/CaM-dependent kinase II (CaMKII). Recently, CaMKII was shown to be activated by methionine oxidation. We investigated whether oxidation-dependent CaMKII activation is involved in the regulation of L-type Ca(2+) currents (I(Ca.L)) by H(2)O(2) and whether Ca(2+) is required in this process. Using patch clamp, I(Ca,L) was measured in rat ventricular myocytes. H(2)O(2) induced an increase in I(Ca,L) amplitude and slowed inactivation of I(Ca.L). This oxidation-dependent facilitation (ODF) of I(ca), L was abolished by a CaMKII blocker KN-93, but not by its inactive analog KN-92, indicating that CaMKII is involved in ODF. ODF was not affected by replacement of external Ca(2+) with Ba(2+) or presence of EGTA in the internal solutions. However, ODF was abolished by adding BAFTA to the internal solution or by depleting sarcoplasmic reticulum (SR) Ca(2+) stores using caffeine and thapsigargin. Alkaline phosphatase, beta-iminoadenosine 5`-triphosphate (AMP-PNP), an autophosphorylation inhibitor autocamtide-2-related inhibitory peptide (Alp), or a catalytic domain blocker (CaM-KIINtide) did not affect ODF. In conclusion, oxidation-dependent facilitation of L-type Ca(2+) channels is mediated by oxidation-dependent CaMKII activation, in which local Ca(2+) increases induced by SR Ca(2+) release is required. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | ko_KR |
dc.subject | Reactive oxygen species | ko_KR |
dc.subject | Ca(2+)/CaM-dependent protein kinase II | ko_KR |
dc.subject | L-type Ca(2+) channels | ko_KR |
dc.subject | L-type Ca(2+) channels | ko_KR |
dc.subject | Sarcoplasmic reticulum Ca(2+) release | ko_KR |
dc.subject | Ca(2+)-dependent facilitation of | ko_KR |
dc.subject | L-type Ca(2+) channels | ko_KR |
dc.subject | Oxidation-dependent facilitation of | ko_KR |
dc.title | L-type Ca(2+) channel facilitation mediated by H(2)O(2)-induced activation of CaMKII in rat ventricular myocytes | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 송연환 | - |
dc.contributor.AlternativeAuthor | 조하나 | - |
dc.contributor.AlternativeAuthor | 류신영 | - |
dc.contributor.AlternativeAuthor | 윤진영 | - |
dc.contributor.AlternativeAuthor | 박선현 | - |
dc.contributor.AlternativeAuthor | 노정일 | - |
dc.contributor.AlternativeAuthor | 이석호 | - |
dc.contributor.AlternativeAuthor | 현원경 | - |
dc.identifier.doi | 10.1016/j.yjmcc.2009.10.020 | - |
dc.citation.journaltitle | JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | - |
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dc.description.tc | 5 | - |
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