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Fas/Fas Ligand-mediated Apoptosis Promotes Hypersensitivity Pneumonitis in Mice by Enhancing Maturation of Dendritic Cells
DC Field | Value | Language |
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dc.contributor.author | Hwang, Su Jin | - |
dc.contributor.author | Kim, Hye Sung | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.date.accessioned | 2012-06-28T01:42:36Z | - |
dc.date.available | 2012-06-28T01:42:36Z | - |
dc.date.issued | 2010-06-01 | - |
dc.identifier.citation | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE; Vol.181 11; 1250-1261 | ko_KR |
dc.identifier.issn | 1073-449X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77711 | - |
dc.description.abstract | Rationale: Fas/Fas ligand (FasL)-mediated apoptosis has been implicated in various lung diseases, but whether Fas/FasL-mediated apoptosis in the lungs plays a critical role in the development of hypersensitivity pneumonitis (HP) is unclear. Objectives: To explore the functional roles of Fas/FasL-mediated apoptosis in HP. Methods: Fas-deficient (lpr/lpr), FasL-deficient (gld/gld), and B6 mice were challenged with Saccharopolyspora rectivirgula (SR) antigen intranasally. Measurements and Main Results: lpr/lpr and gld/gld mice exhibited attenuation of HP in terms of histological alterations, influx of immune cells in bronchoalveolar lavage fluid (BALF), and SR-specific immune responses compared with B6 mice, similar to the effects of SR in B6 mice given a caspase inhibitor. The lungs of lpr/lpr and gld/gld mice showed high IL-4 production and low IFN-gamma, IL-8, macrophage inflammatory protein-2, IL-1 beta, and tumor necrosis factor-alpha production compared with those of B6 mice. Moreover, mice with chimeric B6 and lpr/lpr bone marrow revealed that apoptosis of nonhematopoietic and BALF immune cells of the lungs enhanced immune responses against SR antigen. Gr-1(+) granulocytes in BALF expressed annexin V and their depletion in B6 mice attenuated HP. Apoptosis of nonhematopoietic cells and Gr-1(+) granulocytes in the lungs enhanced the maturation of pulmonary CD11c(+) dendritic cells and their production of macrophage inflammatory protein-1 alpha and monocyte chemoattractant protein-1, resulting in recruitment of immune cells into the lungs during HP. Conclusions: These results suggest that apoptosis in nonhematopoietic cells and Gr-1(+) granulocytes of the lungs promotes HP by enhancing maturation and chemokine production of CD11c(+) dendritic cells. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER THORACIC SOC | ko_KR |
dc.title | Fas/Fas Ligand-mediated Apoptosis Promotes Hypersensitivity Pneumonitis in Mice by Enhancing Maturation of Dendritic Cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 황수진 | - |
dc.contributor.AlternativeAuthor | 김혜성 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.identifier.doi | 10.1164/rccm.200909-1337OC | - |
dc.citation.journaltitle | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | - |
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dc.description.tc | 1 | - |
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