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Adjuvant Radiotherapy after Surgical Resection for Gallbladder Cancer

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Authors
Chie, E.; Kim, K.; Kim, H.; Jang, J.; Oh, D.; Kim, T.; Ha, S. W.; Bang, Y.; Im, S.; Kim, S.
Issue Date
2009
Publisher
ELSEVIER SCIENCE INC
Citation
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS; Vol.75 3; S270-S271
Abstract
Purpose/Objective(s): To analyze the outcome of adjuvant radiotherapy for patients with gallbladder cancer who had undergone
surgical resection, and to identify the prognostic factors for these patients.
Materials/Methods: Between July 1990 and August 2006, 48 patients with gallbladder cancer underwent surgical resection followed
by adjuvant radiotherapy. There were 21 males and 27 females, and median age was 60 years (range; 44-75). Postoperative
radiotherapy was delivered to tumor bed and regional lymph nodes up to 40-50 Gy at 2 Gy per fraction. Forty-one patients also
received intravenous 5-fluorouracil as a radiosensitizer. Median follow-up duration was 25 months for all patients, and 44 months
for survivors.
Results: There were 2 isolated loco-regional recurrences, 13 isolated distant metastases, and 8 combined loco-regional and distant
relapses. Among 42 patients without gross residuum, there were only 4 loco-regional recurrences. The 5-year overall survival rate
(OS) was 42.0%, and median survival time was 30 months. According to the extent of resection, the 5-year OS was 51.8%, 0%, and
0% in R0-, R1-, and R2-resected patients, respectively (p = 0.0012). Patients with T3-4 disease had an inferior 5-year OS compared
with those with T2 disease (35.0% vs. 53.5%, p = 0.0781), whereas treatment outcome was comparable between node-negative and
node-positive disease (5-year OS, 41.2% vs. 49.0%, p = 0.9132). On multivariate analysis incorporating performance status, extent
of resection, T stage, N stage, and histologic differentiation, extent of resection was the only prognostic factor associated with overall
survival (p = 0.0034).
Conclusions: Adjuvant radiotherapy after R0 resection can achieve a long term survival rate in gallbladder cancer patients, even in
those with lymph node metastases.
ISSN
0360-3016
Language
English
URI
http://hdl.handle.net/10371/77712
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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