Publications
Detailed Information
NAFLD INDEX: A SIMPLE SCREENING TOOL REFLECTING NONALCOHOLIC FATTY LIVER DISEASE IN THE KOREAN POPULATION
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J. -H. | - |
dc.contributor.author | Kim, D. | - |
dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Yang, J. I. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Cho, S. -H. | - |
dc.contributor.author | Lee, H. -S. | - |
dc.contributor.author | Sung, M. -W. | - |
dc.contributor.author | Yoon, J. -H. | - |
dc.contributor.author | Kim, W. | - |
dc.date.accessioned | 2012-06-28T01:52:56Z | - |
dc.date.available | 2012-06-28T01:52:56Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | JOURNAL OF HEPATOLOGY; Vol.50 ; S25-S26 | ko_KR |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77716 | - |
dc.description.abstract | Background and Aims: To optimize management of nonalcoholic fatty
liver disease (NAFLD), a simple screening tool is necessary. In this study, we aimed to devise a simple index that reflects the presence of NAFLD in the Korean population. Methods: A cross-sectional study was conducted on 10,724 health checkup subjects at a healthcare center (5,362 cases with NAFLD versus ageand sex-matched controls). Study subjects were randomly assigned to a derivation cohort or a validation cohort. An index reflecting the presence of NAFLD was derived in the derivation cohort and validated in the validation cohort. Results: Multivariable analysis indicated that body-mass index (BMI), serum alanine aminotransferase (ALT) to serum aspartate aminotransferase (AST) ratio, sex, and the presence of diabetes mellitus were independent predictors of NAFLD. Using these variables, a formula was derived using a linear regression model: NAFLD index (NAFLDI) = 8×ALT/AST ratio + BMI (+3, if female; +2, if diabetes mellitus). NAFLDI had an area under receiver-operating characteristics curve of 0.812 (95% confidence interval, 0.801−0.824). At a value of <31.0, NAFLDI ruled out NAFLD with a sensitivity of 89.0% and a negative likelihood ratio of 0.22, and at a value of >36.0, NAFLDI detected NAFLD with a specificity of 91.2% and a positive likelihood ratio of 5.42. In the validation cohort, the predictive power of NAFLDI was maintained at similar levels. NAFLDI had significant correlation with sonographic fatty liver grade (adjusted r2 = 0.334, P<0.001) (Figure 1). Conclusion: NAFLDI was a simple, efficient screening tool for NAFLD that could be utilized for selecting individuals for liver ultrasonography and for determining the need for lifestyle modifications. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE BV | ko_KR |
dc.title | NAFLD INDEX: A SIMPLE SCREENING TOOL REFLECTING NONALCOHOLIC FATTY LIVER DISEASE IN THE KOREAN POPULATION | ko_KR |
dc.type | Article | ko_KR |
dc.citation.journaltitle | JOURNAL OF HEPATOLOGY | - |
dc.description.tc | 0 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.