S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
LONG-TERM PROGNOSIS OF COMBINED HEPATOCELLULAR AND CHOLANGIOCARCINOMA AFTER CURATIVE RESECTION: COMPARISON WITH HEPATOCELLULAR CARCINOMA AND CHOLANGIOCARCINOMA
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- Issue Date
- ELSEVIER SCIENCE BV
- JOURNAL OF HEPATOLOGY; Vol.50 ; S293-S293
- Background and Aims: The prognosis of combined hepatocellular and
cholangiocarcinoma (HCC-CC) has not been fully elucidated. In this study,
we attempted to evaluate the prognosis of HCC-CC with comparison to
hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC).
Methods: This study is retrospective cohort study. Patients who underwent
curative resection for HCC-CC at a single tertiary care center in Seoul,
Korea between January 1988 and December 2005; and their age, sex,
and Child-Turcotte-Pugh (CTP) class matched HCC and CC patients were
included in this study. We evaluated the time-to-recurrence (TTR) and
overall survival (OS) of the HCC-CC cases and compared them to the
HCC and CC patients.
Results: Thirty HCC-CC patients (HCC-CC group), 60 HCC patients
(HCC group) and 60 CC patients (CC group) were included. For the HCCCC
group, the median TTR and OS were 5.4 months and 18.0 months.
After adjustment for confounding factors, the HCC-CC group had a
significantly shorter TTR than did the HCC group (hazard ratio [HR], 2.76;
P<0.001) and the CC group (HR, 2.00; P = 0.013), and a significantly
shorter OS than the HCC group (HR, 4.70; P<0.001). Compared to
the each stage I diseases, HCC-CC had significantly shorter TTR than HCC (HR, 4.59; P = 0.001) and CC (HR, 2.74, P = 0.015) (Fig. 1) and
significantly shorter OS than HCC (HR, 9.35; P = 0.001; Fig. 2).
Conclusion: The results of this study showed that HCC-CC had a significantly
poorer prognosis than HCC and CC. Therefore, close follow-up is
needed for HCC-CC patients with risk factors for a poor prognosis even
after a curative resection.
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