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RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase

Cited 36 time in Web of Science Cited 40 time in Scopus
Authors
Lee, Kyung-Hun; Hur, Hyung-Seok; Im, Seock-Ah; Lee, Juhee; Kim, Hwang-Phill; Yoon, Young-Kwang; Han, Sae-Won; Song, Sang-Hyun; Oh, Do-Youn; Kim, Tae-You; Bang, Yung-Jue
Issue Date
2010-12
Publisher
ELSEVIER IRELAND LTD
Citation
Cancer Letters, Vol.299 No.1, pp.22-28
Keywords
Gastric cancerRAD001mTORThymidylate synthase
Abstract
We evaluated RAD001 an inhibitor of the mammalian target of rapamycin (mTOR) in human gastric cancer cell lines and determined the molecular mechanisms RAD001 has marked growth inhibitory activity against the SNU-1 and SNU-216 cells It inhibited phosphorylation of mTOR and S6 K and induced Cl cell cycle arrest Synergistic growth inhibitory effects in combination with 5-fluorouracil (5-FU) was identified Furthermore RAD001 conferred sensitivity to 5-FU-resistant cell lines by downregulating thymidylate synthase (TS) In conclusion RAD001 showed growth inhibitory activity against gastric cancer cells and acted synergistically with cytotoxic agents such as 5-FU by downregulating TS (C) 2010 Elsevier Ireland Ltd All rights reserved
ISSN
0304-3835
Language
English
URI
https://hdl.handle.net/10371/77724
DOI
https://doi.org/10.1016/j.canlet.2010.07.020
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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