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Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia

Cited 9 time in Web of Science Cited 10 time in Scopus
Authors
Lee, Hyun Ju; Choi, Chang Won; Kim, Beyong Il; Kim, Ee-Kyung; Choi, Jung-Hwan; Yang, Eun Gyeong; Lee, Myong Jin; Kim, Han-Suk
Issue Date
2010-11
Publisher
WALTER DE GRUYTER & CO
Citation
JOURNAL OF PERINATAL MEDICINE; Vol.38(6); 675-681
Keywords
Bronchopulmonary dysplasiachorioamnionitisinterleukin-6vascular endothelial growth factorprotein carbonyl
Abstract
Aim: To investigate serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia (BPD) induced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85%). Methods: We evaluated histological changes of the lungs and compared the levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and protein carbonyl in lung tissue on days 1, 7, and 14 after birth in a rat model of BPD. Results: The inhibition of alveolarization was sustained in the LPS plus hyperoxia group from day 7 to 14, whereas alveolarization resumed in the hyperoxia group after oxygen exposure was withdrawn at day 7. Administration of LPS alone did not adversely affect lung morphometry. IL-6 levels showed transient overexpression at day 1 in the LPS-treated groups, but decreased at days 7 and 14. VEGF protein levels were elevated in the LPS-treated groups, but not in the hyperoxia and control groups at days 1, 7, and 14. Exposure to hyperoxia affected protein carbonyl levels in the hyperoxia group at days 7 and 14. Conclusion: Lung injury induced by intra-amniotic inflammation and postnatal hyperoxia may be due to inhibition of alveolarization without recovery even after withdrawal of oxygen.
ISSN
0300-5577
Language
English
URI
http://hdl.handle.net/10371/77726
DOI
https://doi.org/10.1515/JPM.2010.091
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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