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Time-dependent differential gene expression in lysophosphatidic acid-treated young and senescent human diploid fibroblasts

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dc.contributor.authorRhim, Ji-Heon-
dc.contributor.authorJang, Ik-Soon-
dc.contributor.authorChoi, Jong-Soon-
dc.contributor.authorKwon, Hyun Jin-
dc.contributor.authorPark, Sang Chul-
dc.contributor.authorYeo, Eui-Ju-
dc.date.accessioned2012-06-28T02:34:25Z-
dc.date.available2012-06-28T02:34:25Z-
dc.date.issued2009-09-
dc.identifier.citationMECHANISMS OF AGEING AND DEVELOPMENT; Vol.130(9); 648-651ko_KR
dc.identifier.issn0047-6374-
dc.identifier.urihttps://hdl.handle.net/10371/77734-
dc.description.abstractThe gene expression profiles of lysophosphatidic acid (LPA)-treated young and senescent human diploid fibroblasts (HDFs) were examined using cDNA microarray analysis. The expression of some genes, including EGR 1/3 and MRRF, was controlled by LPA similarly in young and senescent cells, showing a typical time-dependent up-and-down expression profile. In contrast, some other genes, including DUSP6, CYR61, and F3, showed sustained upregulation in senescent HDFs later after LPA treatment. These genes might be involved in altered LPA responsiveness during the aging process.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectDifferential gene expressionko_KR
dc.subjectSenescent HDFsko_KR
dc.subjectcDNA microarray analysisko_KR
dc.subjectHuman diploid fibroblastsko_KR
dc.subjectLysophosphatidic acidko_KR
dc.titleTime-dependent differential gene expression in lysophosphatidic acid-treated young and senescent human diploid fibroblastsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor임지헌-
dc.contributor.AlternativeAuthor장익순-
dc.contributor.AlternativeAuthor최종순-
dc.contributor.AlternativeAuthor권현진-
dc.contributor.AlternativeAuthor여의주-
dc.contributor.AlternativeAuthor박상철-
dc.identifier.doi10.1016/j.mad.2009.06.007-
dc.citation.journaltitleMECHANISMS OF AGEING AND DEVELOPMENT-
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dc.description.tc1-
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