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Expression of MMP-2, MMP-9, and Urokinase-Type Plasminogen Activator in Cervical Intraepithelial Neoplasia
DC Field | Value | Language |
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dc.contributor.author | No, Jae Hong | - |
dc.contributor.author | Jo, Hoenil | - |
dc.contributor.author | Kim, Su-Hyeong | - |
dc.contributor.author | Park, In-Ae | - |
dc.contributor.author | Lee, Chae Hyeong | - |
dc.contributor.author | Kim, Jae Weon | - |
dc.contributor.author | Kang, Soon-Beom | - |
dc.contributor.author | Song, Yong-Sang | - |
dc.contributor.author | Park, Noh-Hyun | - |
dc.contributor.author | Han, Seung-Su | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2012-06-28T04:54:56Z | - |
dc.date.available | 2012-06-28T04:54:56Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS; Vol.1171 ; 100-104 | ko_KR |
dc.identifier.issn | 0077-8923 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77750 | - |
dc.description.abstract | Matrix metalloproteinase-2 (MMP-2), MMP-9, and urokinase-type plasminogen activator (uPA) are important factors for cancer invasion and metastasis, degrading the extracellular matrix. They are also associated with angiogenesis. Angiogenic phenotype is another feature of high-grade cervical intraepithelial neoplasia (CIN). However, their associations with the progression of low-grade CIN to high-grade CIN are unexplored. We investigated whether these proteolytic enzyme expressions correlate with the progression of CIN. A total of 39 paraffin-embedded specimens from 10 patients with CIN grade 1, nine with CIN grade 2, and 20 with CIN grade 3 were assessed immunohistochemically by specific antibodies against MMP-2, MMP-9, and uPA. MMP-9 expression was higher in CIN 3 lesions (47.4%) than in CIN 1 (22.2%) and CIN 2 (20.2%) lesions, although the difference failed to reach statistical significance. The expression level of uPA and MMP-2 was not associated with the grade of CIN lesions. Interestingly, we found a significant association between expressions of uPA and MMP-2 (P = 0.028). Our results suggest that MMP-9 might play a role in the progression of CIN. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BLACKWELL PUBLISHING | ko_KR |
dc.subject | cervical intraepithelial neoplasia | ko_KR |
dc.subject | matrix metalloproteinase | ko_KR |
dc.subject | urokinase-type plasminogen activator | ko_KR |
dc.title | Expression of MMP-2, MMP-9, and Urokinase-Type Plasminogen Activator in Cervical Intraepithelial Neoplasia | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 노재홍 | - |
dc.contributor.AlternativeAuthor | 조헌일 | - |
dc.contributor.AlternativeAuthor | 김수형 | - |
dc.contributor.AlternativeAuthor | 박인애 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.contributor.AlternativeAuthor | 이채형 | - |
dc.contributor.AlternativeAuthor | 한승수 | - |
dc.contributor.AlternativeAuthor | 김재원 | - |
dc.contributor.AlternativeAuthor | 박노현 | - |
dc.contributor.AlternativeAuthor | 강순범 | - |
dc.contributor.AlternativeAuthor | 송용상 | - |
dc.identifier.doi | 10.1111/j.1749-6632.2009.04898.x | - |
dc.citation.journaltitle | NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS | - |
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dc.description.tc | 2 | - |
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