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RELATIONSHIP BETWEEN POLYMORPHISMS OF INSULIN-LIKE GROWTH FACTOR (IGF) GENES AND ENDOMETRIOSIS IN KOREAN WOMEN
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. G. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Ku, S. -Y. | - |
dc.contributor.author | Kim, S. H. | - |
dc.contributor.author | Choi, Y. M. | - |
dc.date.accessioned | 2012-06-28T05:03:42Z | - |
dc.date.available | 2012-06-28T05:03:42Z | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | FERTILITY AND STERILITY; Vol.94 4; S203-S203 | ko_KR |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77756 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to investigate the relationship
between the polymorphisms of the IGF-II, IGF-I and its receptor genes and endometriosis in Korean women. DESIGN: A case - control study. MATERIALS AND METHODS: The IGF-I -969 (CA) block, A(-603)T, and T(-553)C polymorphisms, and IGF-II c.517 C>T, c.540 G>T, and 820 G>A polymorphisms, and IGF-I receptor c.3129 G>A polymorphism were analyzed in women with (n¼129) and without endometriosis (n¼108) and male neonates(n¼122) by GeneScan, direct sequencing and restriction fragment length polymorphism. Women without endometriosis and male neonates were served as controls. Clinical stage was classified according to the revised American Fertility Society Classification. RESULTS: The IGF-I T(-553)C, IGF-II II c.517 C>T, and c.540 G>T polymorphisms were not observed. Among polymorphisms measured, the IGF-I receptor c.3129 G>A, and IGF-II 820 G>A polymorphisms were associated with endometriosis. AA genotype of the IGF-I receptor c.3129G>A polymorphism had lower risk of endometriosis (odds ratio: 0.52, 95% confidence level: 0.31-0.87) compared with other genotype, whileGG genotype of IGF-II 820 G>A polymorphism showed 2.3 times higher risk of endometriosis compared with non GG genotype. These relationships were observed in early stage endometriosis (stage I + stage II), but not in late stage endometriosis (stage III + stage IV). CONCLUSION: The IGF-I receptor c.3129 G>A, and IGF-II 820 G>A polymorphisms are genetic factors which may be associated with endometriosis in Korean women. | ko_KR |
dc.description.sponsorship | Supported by: National Research Foundation ofKorea Grant funded by the
Korean Government (2009-0070751). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.title | RELATIONSHIP BETWEEN POLYMORPHISMS OF INSULIN-LIKE GROWTH FACTOR (IGF) GENES AND ENDOMETRIOSIS IN KOREAN WOMEN | ko_KR |
dc.type | Article | ko_KR |
dc.citation.journaltitle | FERTILITY AND STERILITY | - |
dc.description.tc | 0 | - |
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