CHEMOTHERAPY-ASSOCIATED HEPATOPATHY IN COLORECTAL CANCER LIVER METASTASIS PATIENTS

Abstract

Background and Aims: Oxaliplatin, irinotecan and 5-fluorouracil (5-FU)-based preoperative chemotherapy is increasingly used in patients with colorectal cancer liver metastases (CRLM). Although chemotherapy-related hepatopathy (CAH) has been described, its impact on postoperative outcome remains controversial. The purpose of our study was to review the effects of preoperative chemotherapy in CRLM patients on liver histology and on postoperative outcome.