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Preventive effects of COX-2 inhibitor, celecoxib on renal tubular injury induced by shock wave lithotriptor

Cited 8 time in Web of Science Cited 7 time in Scopus
Authors
Park, Hyoung Keun; Lee, Hae Won; Lee, Kwang Soo; Choi, Jong Sun; Kim, Hyeon Hoe; Jeong, Byong Chang
Issue Date
2010-08
Publisher
SPRINGER
Citation
UROLOGICAL RESEARCH; Vol.38; no.4; 223-228
Keywords
KidneyCOX-2 inhibitorsExtracorporeal shockwave lithotripsy
Abstract
Our study was designed to investigate the protective
eVect of the COX-2 inhibitor, celecoxib, on renal
tubules against shock wave lithotripsy (SWL). Sprague–
Dawley rats were randomly divided into three groups:
sham, control, and COX-2 groups. The control group was
administrated normal saline. The COX-2 group was administered
celecoxib (10 mg/kg). After administration for
1 week, the control and COX-2 groups received 1,000
shock waves. Before and after SWL, 24-h urine was collected.
CCr was measured to assess renal function. To
determine the renal tubular injury, N-acetyl glucosaminidase
(NAG) and -2 microglobulin levels in urine were
quantiWed. The COX-2 gene expression was compared
between the three groups. Prior to SWL, all groups had
similar levels of NAG and -2 microglobulin. After SWL,
all groups showed similar CCr. Compared with the sham
group, control and COX-2 groups produced increase of
NAG and -2 microglobulin excretion. However, NAG and
-2 microglobulin excretions were signiWcantly lower in
the COX-2 group than control group. The COX-2 gene expression did not increase in the sham group. However,
the COX-2 gene expression was signiWcantly increased in
the control group, which was prevented by celecoxib in
COX-2 group. Biochemical Wndings supported a renal protective
eVect of celecoxib on SWL. This study suggests that
celecoxib would be useful prior and after SWL because of
renal protective eVects.
ISSN
0300-5623
Language
English
URI
http://hdl.handle.net/10371/77772
DOI
https://doi.org/10.1007/s00240-009-0243-z
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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