S-Space College of Medicine/School of Medicine (의과대학/대학원) Obstetrics & Gynecology (산부인과전공) Journal Papers (저널논문_산부인과학전공)
Intra-amniotic infection with genital mycoplasmas is characterized by an intense inflammatory response in the amniotic cavity and in the maternal compartment
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- Issue Date
- AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY; Vol.201 6; S165-S166
- OBJECTIVE: Genital mycoplasmas are the most frequent organisms responsible
for intra-amniotic infection. Yet, they are considered to be
less virulent than other bacteria. The purpose of this study was to compare the intensity of intra-amniotic and maternal inflammatory
responses between cases of intra-amniotic infection (IAI) caused by
genital mycoplasmas and IAI caused by other microorganisms.
STUDY DESIGN: We studied the magnitude of the inflammatory response
in 93 patients with preterm PROM and a positive amniotic
fluid (AF) culture for microorganisms. Patients were divided into 2
groups: 1) those with genital mycoplasmas in the AF (ureaplasmas
and/or Mycoplasma hominis, n 62); and 2) cases with other microorganisms
(n 31). Patients with mixed infections (genital mycoplasmas
and other microorganisms) were excluded. The intensity of intraamniotic
inflammatory response was determined by the AF white
blood cell (WBC) count, and that of the maternal inflammatory response
was assessed by the concentration of C-reactive protein (CRP)
and WBC count in maternal blood at the time of amniocentesis.
RESULTS: 1) The median AF WBC count, maternal blood WBC count
and plasma CRP concentration were significantly higher in cases with
IAI caused by genital mycoplasmas than in those with IAI with other
microorganisms (p 0.05 for each); and 2) there were no significant
differences in maternal age, parity, gestational age at amniocentesis,
rupture of membranes-to-amniocentesis interval, and use of corticosteroids
and antibiotics before amniocentesis between the two groups.
CONCLUSION: 1) Intra-amniotic infection caused by genital mycoplasmas
results in a more intense inflammatory response in the amniotic
cavity as well as in the maternal compartment than those caused by
other microorganisms; 2) it is possible that chronicity can account for
the more severe magnitude of intra-amniotic and maternal inflammatory
response reported herein.
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