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Direct visualization of deep brain stimulation targets in Parkinson disease with the use of 7-tesla magnetic resonance imaging Clinical article

Cited 117 time in Web of Science Cited 119 time in Scopus
Authors
Cho, Zang-Hee; Min, Hoon-Ki; Oh, Se-Hong; Han, Jae-Yong; Chi, Je-Geun; Paek, Sun Ha; Lee, Kendall H.; Lozano, Andres M.; Kim, Young-Bo; Park, Chan-Woong
Issue Date
2010-09
Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
Citation
JOURNAL OF NEUROSURGERY; Vol.113 3; 639-647
Keywords
deep brain stimulation7-tesla magnetic resonance imaginginternal globus pallidussubthalamic nucleusParkinson disease
Abstract
Object. A challenge associated with deep brain stimulation (DBS) in treating advanced Parkinson disease (PD) is the direct visualization of brain nuclei, which often involves indirect approximations of stereotactic targets. In the present study, the authors compared T2*-weighted images obtained using 7-T MR imaging with those obtained using 1.5- and 3-T MR imaging to ascertain whether 7-T imaging enables better visualization of targets for DBS in PD. Methods. The authors compared 1.5-, 3-, and 7-T MR images obtained in 11 healthy volunteers and 1 patient with PD. Results. With 7-T imaging, distinct images of the brain were obtained, including the subthalamic nucleus (STN) and internal globus pallidus (GPi). Compared with the 1.5- and 3-T MR images of the STN and GPi, the 7-T MR images showed marked improvements in spatial resolution, tissue contrast, and signal-to-noise ratio. Conclusions. Data in this study reveal the superiority of 7-T MR imaging for visualizing structures targeted for DBS in the management of PD. This finding suggests that by enabling the direct visualization of neural structures of interest, 7-T MR imaging could be a valuable aid in neurosurgical procedures. (DOI: 10.3171/2010.3.JNS091385)
ISSN
0022-3085
Language
English
URI
https://hdl.handle.net/10371/77784
DOI
https://doi.org/10.3171/2010.3.JNS091385
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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