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Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis

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dc.contributor.authorPark, Wan Beom-
dc.contributor.authorKim, Won-
dc.contributor.authorLee, Kook Lae-
dc.contributor.authorYim, Jae-Joon-
dc.contributor.authorJung, Yong Jin-
dc.contributor.authorKim, Dong Hee-
dc.contributor.authorYoon, Jung-Hwan-
dc.contributor.authorLee, Hyo Suk-
dc.contributor.authorOh, Myoung-don-
dc.contributor.authorKim, Yoon Jun-
dc.contributor.authorKim, Nam Joong-
dc.contributor.authorKim, Moonsuk-
dc.identifier.citationJOURNAL OF INFECTION; Vol.61 4; 323-329ko_KR
dc.description.abstractObjectives: To evaluate the incidence, risk factors and outcomes for anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic liver disease including cirrhosis. Methods: A total of 107 patients with chronic liver disease were assessed for anti-TB DILI. Anti-TB DILI was defined as elevation of alkaline phosphatase (ALP), aspartate transaminase, or alanine transaminase, or an increase in Child-Turcotte-Pugh score within 2 months of initiating anti-TB medication. The risk factors for anti-TB DILI were evaluated by multivariate logistic regression analysis. Results: Fifty-eight (54%) patients had cirrhosis. Of 93 patients receiving one or more hepatotoxic anti-TB drugs, 18 (17%) experienced DILI: 11 (24%) among 46 patients with chronic hepatitis and 7 (15%) among 46 patients with compensated liver cirrhosis (P = 0.271). Independent risk factors for DILI were female sex, number of hepatotoxic anti-TB drugs administered and baseline ALP levels but not cirrhosis itself. Of the 18 patients with DILI, 13 (72%) successfully completed anti-TB treatment after switching to less hepatotoxic drug regimens. Conclusions: Hepatotoxic anti-TB drugs may be safely used in the patients with chronic liver disease including compensated cirrhosis if number of hepatotoxic drugs used is adjusted appropriately. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.ko_KR
dc.publisherW B SAUNDERS CO LTDko_KR
dc.subjectChronic hepatitisko_KR
dc.subjectLiver diseaseko_KR
dc.subjectDrug toxicityko_KR
dc.titleAntituberculosis drug-induced liver injury in chronic hepatitis and cirrhosisko_KR
dc.citation.journaltitleJOURNAL OF INFECTION-
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