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A microneedle roller for transdermal drug delivery

Cited 98 time in Web of Science Cited 103 time in Scopus
Authors
Park, Jung-Hwan; Choi, Seong-O; Seo, Soonmin; Bin Choy, Young; Prausnitz, Mark R.
Issue Date
2010-10
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; Vol.76 2; 282-289
Keywords
MicroneedleFabricationDrug delivery propertyMechanical propertyPolymer film
Abstract
Microneedle rollers have been used to treat large areas of skin for cosmetic purposes and to increase skin permeability for drug delivery. In this study, we introduce a polymer microneedle roller fabricated by inclined rotational UV lithography, replicated by micromolding hydrophobic polylactic acid and hydrophilic carboxy-methyl-cellulose. These microneedles created micron-scale holes in human and porcine cadaver skin that permitted entry of acetylsalicylic acid. Trypan blue and nanoparticles measuring 50 nm and 200 nm in diameter. The amount of acetylsalicylic acid delivered increased with the number of holes made in the skin and was 1-2 orders of magnitude greater than in untreated skin. Lateral diffusion in the skin between holes made by microneedles followed expected diffusional kinetics, with effective diffusivity values that were 23-160 times smaller than in water. Compared to inserting microneedles on a flat patch, the sequential insertion of microneedles row by row on a roller required less insertion force in full-thickness porcine skin. Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery. (C) 2010 Elsevier B.V. All rights reserved.
ISSN
0939-6411
Language
English
URI
https://hdl.handle.net/10371/77812
DOI
https://doi.org/10.1016/j.ejpb.2010.07.001
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College of Medicine/School of Medicine (의과대학/대학원)Biomedical Engineering (의공학전공)Journal Papers (저널논문_의공학전공)
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