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How to Overcome Retinal Neuropathy: The Fight against Angiogenesis-related Blindness

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dc.contributor.authorJo, Dong Hyun-
dc.contributor.authorKim, Jin Hyoung-
dc.contributor.authorKim, Jeong Hun-
dc.date.accessioned2012-06-29T00:16:47Z-
dc.date.available2012-06-29T00:16:47Z-
dc.date.issued2010-10-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH; Vol.33 10; 1557-1565ko_KR
dc.identifier.issn0253-6269-
dc.identifier.urihttps://hdl.handle.net/10371/77835-
dc.description.abstractThe retina consists of neuronal cells of high metabolic activity that are supplied by an abundant vasculature. It is a main theme of ophthalmologic research, because retinopathies are common causes of blindness in all age groups: age-related macular degeneration in the elderly, diabetic retinopathy in the middle aged, and retinopathy of prematurity and retinoblastoma in children. Interestingly, angiogenesis underlies the pathogenesis of all these diseases, and breakdown of the blood-retinal barrier is also thought to play an important role before and throughout the process of new vessel formation. However, so far, most treatments have targeted angiogenesis only, especially vascular endothelial growth factor. Consideration of the restoration of the blood-retinal barrier should be required. In this review, we discuss the clinical manifestation, pathogenesis, and current treatment options for angiogenesis-related blindness. In addition, because of the recent introduction of novel strategies, we describe pathogenesis-based treatment options to treat angiogenesis-related blindness.ko_KR
dc.language.isoenko_KR
dc.publisherPHARMACEUTICAL SOC KOREAko_KR
dc.subjectAngiogenesis-related blindnessko_KR
dc.subjectAge-related macular degenerationko_KR
dc.subjectRetinopathy of prematurityko_KR
dc.subjectRetinoblastomako_KR
dc.subjectDiabetic retinopathyko_KR
dc.titleHow to Overcome Retinal Neuropathy: The Fight against Angiogenesis-related Blindnessko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor조동현-
dc.contributor.AlternativeAuthor김진형-
dc.contributor.AlternativeAuthor김정훈-
dc.identifier.doi10.1007/s12272-010-1007-6-
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